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Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment

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González Ortiz, Blanca and Colilla, Montserrat and Díez, Jaime and Pedraza, Daniel and Guembe, Marta and Izquierdo-Barba, Isabel and Vallet Regí, María (2018) Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment. Acta Biomaterialia, 68 . pp. 261-271. ISSN 1742-7061

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Abstract

This work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, thus increasing the antimicrobial effectiveness. These nanosystems, named "nanoantibiotics", are composed of mesoporous silica nanoparticles (MSNs), which act as nanocarriers of an antimicrobial agent (levofloxacin, LEVO) localized inside the mesopores. To provide the nanosystem of bacterial membrane interaction capability, a polycationic dendrimer, concretely the poly(propyleneimine) dendrimer of third generation (G3), was covalently grafted to the external surface of the LEVOloaded MSNs. After physicochemical characterization of this nanoantibiotic, the release kinetics of LEVO and the antimicrobial efficacy of each released dosage were evaluated. Besides, internalization studies of the MSNs functionalized with the G3 dendrimer were carried out, showing a high penetrability throughout Gram-negative bacterial membranes. This work evidences that the synergistic combination of polycationic dendrimers as bacterial membrane permeabilization agents with LEVO-loaded MSNs triggers an efficient antimicrobial effect on Gram-negative bacterial biofilm. These positive results open up very promising expectations for their potential application in new infection therapies.


Item Type:Article
Additional Information:

RESEARCHER ID K-4773-2015 (Blanca González Ortiz)
ORCID 0000-0002-0493-6071 (Blanca González Ortiz)
RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous Silica Nanoparticles, Polycationic dendrimers, Bacterial internalization, Antimicrobial delivery, Biofilm, Infection treatment
Subjects:Sciences > Chemistry > Materials
Medical sciences > Medicine > Communicable diseases
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:45947
Deposited On:13 Feb 2018 10:09
Last Modified:13 Feb 2018 10:49

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