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Neural-derived estradiol regulates brain plasticity

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Azcoitia Elías, Iñigo and Arévalo, María Ángeles and García Segura, Luis Miguel (2016) Neural-derived estradiol regulates brain plasticity. Journal of Chemical Neuroanatomy . ISSN 0891-0618

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Official URL: https://www.journals.elsevier.com/journal-of-chemical-neuroanatomy/



Abstract

In addition to be an ovarian hormone, estradiol is a neurosteroid synthesized by neural cells. The brain is a steroidogenic tissue that metabolizes testosterone to estradiol. The last step in the synthesis of estradiol is catalyzed by the enzyme aromatase, which is widely expressed in the brain of male and female animals and humans. Studies that have manipulated the expression or the activity of aromatase have revealed that brain-derived estradiol acts as a neuromodulator and regulates different forms of brain plasticity in male and female animals. The regulation of neuroplastic events by brain-derived estradiol probably participates in the effects of brain aromatase on behavior and cognition.


Item Type:Article
Uncontrolled Keywords:Aromatase; Dendritic spines; Estradiol;Long-term depression; Long-term potentiation; Songbirds Synaptic plasticity
Subjects:Medical sciences > Biology > Cytology
ID Code:46371
Deposited On:07 Feb 2018 17:58
Last Modified:23 May 2018 08:23

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