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Mesoporous Silica Nanoparticles Engineered for Ultrasound-Induced Uptake by Cancer Cells

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Paris, J.L. and Manzano García, Miguel and Cabañas Criado, Maria Victoria and Vallet Regí, María (2018) Mesoporous Silica Nanoparticles Engineered for Ultrasound-Induced Uptake by Cancer Cells. Nanoscale . ISSN 2040-3364

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Abstract

A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is here presented. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively-charged surface. That favors the internalization in human osteosarcoma cells, where release of topotecan takes place, drastically enhancing the cytotoxic effect.


Item Type:Article
Additional Information:

RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente)
ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)
ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:46645
Deposited On:12 Mar 2018 09:18
Last Modified:28 Feb 2019 00:01

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