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Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts.

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Castillo Romero, Rafael and Hernández-Escobar, David and Gómez Graña, Sergio and Vallet Regí, María (2018) Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts. Chemistry - A European Journal . ISSN 1521-3765

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Abstract

The implementation of nanoparticles as nanomedicines require from sophisticated surface modifications in order to reduce immune response and enhance recognition abilities. In addition to that, Mesoporous Silica nanoparticles present extraordinary host-guest abilities and facile surface functionalization. These two factors make them ideal candidates for the development of
novel drug delivery systems, at the expense of increasing the structural complexity. With this idea in mind, a system of triggerable and tunable silica nanoparticles was developed for its application as drug delivery nanocarriers. For that purpose, Diels-Alder cycloaddition adducts were chosen as thermalresponsive units; that permitted to bind Au nanocaps able to block the pores and allow the incorporation of targeting fragments. The capping efficiency was tested under different thermal conditions, obtaining outstanding efficiencies within the physiological range and mild temperatures, as well as enhanced releases under pulsing heating cycles which showed the best release profiles.


Item Type:Article
Additional Information:

RESEARCHER ID L-2854-2014 (Rafael Castillo Romero)
ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)
RESEARCHER ID G-7562-2016 (Sergio Gómez Graña)
ORCID 0000-0002-7736-051X (Sergio Gómez Graña)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica, Silica-Au nanocomposites, Mesopore reversible gating, Diels-Alder, Targeting
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:46677
Deposited On:12 Mar 2018 09:33
Last Modified:02 Mar 2019 00:01

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