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Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1; Referees:4:approved]

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Aguilar-Cuenca, Rocío and Llorente-González, Clara and Vicente Córdoba, Carlos and Vicente Manzanares, M. (2017) Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1; Referees:4:approved]. F1000Research, 6 (160). pp. 1-15. ISSN 2046-1402, ESSN: 2046-1402

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Official URL: https://f1000research.com/articles/6-160/v1



Abstract

Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while moving directionally. Adhesive coordination is paramount in physiological contexts (for example, during organogenesis) but also in pathology (for example, tumor metastasis). In this review, we address the need for a coordinated regulation of cell-cell and cell-matrix adhesions during collective cell migration. We emphasize the role of the actin cytoskeleton as an intracellular integrator of cadherin- and integrin-based adhesions and the emerging role of mechanics in the maintenance, reinforcement, and turnover of adhesive contacts. Recent advances in understanding the mechanical regulation of several components of cadherin and integrin adhesions allow us to revisit the adhesive clutch hypothesis that controls the degree of adhesive engagement during protrusion. Finally, we provide a brief overview of the major impact of these discoveries when using more physiological three-dimensional models of single and collective cell migration.


Item Type:Article
Uncontrolled Keywords:Cell adhession; Cell migration; Tissues
Subjects:Medical sciences > Biology > Cytology
ID Code:46893
Deposited On:15 Mar 2018 12:51
Last Modified:09 Apr 2019 09:11

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