Publication: Calidad de vida en niños con patología obstructiva de la vía aérea central
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2018-03-20
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Universidad Complutense de Madrid
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Abstract
La patología obstructiva de la vía aérea central (POVAC) incluye las situaciones clínicas en las que existe una obstrucción anatómica o funcional al flujo aéreo desde la laringe a los bronquios segmentarios. La calidad de vida relacionada con la salud (CVRS) es un aspecto muy importante en la patología respiratoria en general, tanto en la evaluación diagnóstica inicial como en la valoración de la respuesta a las intervenciones terapéuticas médicas o quirúrgicas. Existe poca información sobre la CVRS de los niños con POVAC, tanto global o como relacionada con los problemas respiratorios. Objetivos: Cuantificar la CVRS respiratoria y global de los niños con POVAC mediante los cuestionarios PACQLQ adaptado y TAPQOL®, compararla con la de los niños con patología de la vía aérea periférica (asma), y determinar la fiabilidad y validez de los cuestionarios utilizados en esta población. Pacientes y métodos: Se estudiaron dos grupos de niños. El grupo de estudio (POVAC) tuvo como criterios de inclusión el diagnóstico previo de POVAC en nuestro centro y el consentimiento informado para participar en el estudio y el grupo de comparación (ASMA), el diagnóstico previo de asma y el consentimiento informado para participar en el estudio. Se previó un tamaño muestral de 100 niños en cada grupo. Los instrumentos de medida fueron un cuestionario adaptado del Paediatric Asthma Caregiver Quality of Life (PACQLQ) para la CVRS respiratoria y TAPQOL® para la CVRS global, ambos autocumplimentados. Los criterios de valoración principal fueron las puntuaciones obtenidas en los cuestionarios. Se compararon estos criterios entre ambos grupos mediante la regresión lineal múltiple para controlar posibles diferencias en las variables demográficas. La fiabilidad se valoró por el estadístico alfa de Cronbach y la validez, mediante un Análisis de Componentes Principales (ACP) realizado con el procedimiento FACTOR del programa estadístico SPSS...
Paediatric Central Airway Obstructive Disease (PCAOD) includes clinical conditions with anatomical or functional airflow obstruction form larynx to segmental bronchi. Health Related Quality of life (HRQL) is a very important issue in respiratory conditions, both in the initial clinical evaluation and in assessing the response to medical or surgical interventions. There is scarce information on respiratory or global HRQL in children with PCAOD. Objectives: To assess respiratory and global HRQL in children with POVAC using an adapted Paediatric Asthma Caregiver Quality of Life (PACQLQ) and TAPQOL questionnaires, to compare their results with those obtained in children with asthma and to assess the reliability and validity of these questionnaires when used in these children populations. Subjects and methods. Two groups of children were studied. The study group (PCAOD) inclusion criteria included a previous diagnosis of PCAOD in our centre and informed consent to participate in the study, and the comparison group (ASTHMA) inclusion criteria, previous diagnosis of asthma and informed consent to participate in the study. The target sample size was 100 in both groups. An adapted PACQLQ and TAPQOL self-administered questionnaires were used to assess respiratory and global HRQL, respectively. Scores obtained with both questionnaires were the study primary endpoints. Multiple linear regression was used to compare primary endpoints among groups controlling for possible differences in demographic variables. Cronbach’s alpha was used to assess reliability and Principal Component Analysis (PCA) performed with SPSS software FACTOR procedure to assess validity. Results: During the recruitment period from March 2015 to September 2016, 109 children (55 males, mean age [SD] 4.8 [4.8] years) were included in PCAOD group and 100 (64 males, mean age [SD] 8.3 [2.9] years) in ASTHMA group. Mean [SD] adapted PACQLQ total score was 5.01 [1.70] and 5.99 [1.04] in CPCAOD and ASTHMA groups, respectively, with a controlled difference of 0.56 [95% Confidence Interval 0.99 – 0.14], which represents 0.39 standard deviations (Cohen’s d statistics)...
Paediatric Central Airway Obstructive Disease (PCAOD) includes clinical conditions with anatomical or functional airflow obstruction form larynx to segmental bronchi. Health Related Quality of life (HRQL) is a very important issue in respiratory conditions, both in the initial clinical evaluation and in assessing the response to medical or surgical interventions. There is scarce information on respiratory or global HRQL in children with PCAOD. Objectives: To assess respiratory and global HRQL in children with POVAC using an adapted Paediatric Asthma Caregiver Quality of Life (PACQLQ) and TAPQOL questionnaires, to compare their results with those obtained in children with asthma and to assess the reliability and validity of these questionnaires when used in these children populations. Subjects and methods. Two groups of children were studied. The study group (PCAOD) inclusion criteria included a previous diagnosis of PCAOD in our centre and informed consent to participate in the study, and the comparison group (ASTHMA) inclusion criteria, previous diagnosis of asthma and informed consent to participate in the study. The target sample size was 100 in both groups. An adapted PACQLQ and TAPQOL self-administered questionnaires were used to assess respiratory and global HRQL, respectively. Scores obtained with both questionnaires were the study primary endpoints. Multiple linear regression was used to compare primary endpoints among groups controlling for possible differences in demographic variables. Cronbach’s alpha was used to assess reliability and Principal Component Analysis (PCA) performed with SPSS software FACTOR procedure to assess validity. Results: During the recruitment period from March 2015 to September 2016, 109 children (55 males, mean age [SD] 4.8 [4.8] years) were included in PCAOD group and 100 (64 males, mean age [SD] 8.3 [2.9] years) in ASTHMA group. Mean [SD] adapted PACQLQ total score was 5.01 [1.70] and 5.99 [1.04] in CPCAOD and ASTHMA groups, respectively, with a controlled difference of 0.56 [95% Confidence Interval 0.99 – 0.14], which represents 0.39 standard deviations (Cohen’s d statistics)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Pediatría, leída el 24/06/2017