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Beyond Traditional Hyperthermia. In vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

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Guisasola, Eduardo and Asin, Laura and Beola, Lillianne and De la Fuente, J. M. and Baeza, Alejandro and Vallet Regí, María (2018) Beyond Traditional Hyperthermia. In vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers. ACS Applied Materials and Interfaces, 10 (15). pp. 12518-12525. ISSN 1944-8244

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Official URL: https://pubs.acs.org/




Abstract

In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores. By a synergic effect between the intracellular hyperthermia and chemotherapy triggered by AMF application, significant tumor growth inhibition was achieved in 48 hours after treatment.
Furthermore, the small magnetic loading used in the experiments indicates that the treatment is carried out without a global temperature rise of the tissue, which avoids the problem of the necessity to employ large amounts of magnetic cores, as is common in current magnetic hyperthermia.


Item Type:Article
Additional Information:

RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)
ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Hot spot, Stimuli-responsive, Drug delivery, Magnetic hyperthermia, Synergic therapy, Silica mesoporous nanoparticles, Thermosensitive polymer
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:46996
Deposited On:18 Apr 2018 08:42
Last Modified:22 Mar 2019 00:01

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