Publication: Leche enriquecida con esteroles vegetales en pacientes pediátricos con hipercolesterolemia. Ensayo clínico doble ciego, controlado y aleatorizado
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2018-04-03
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Universidad Complutense de Madrid
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Abstract
La dislipemia es un reconocido factor de riesgo de enfermedad cardiovascular (ECV). Objetivos: Determinar la eficacia de leche desnatada enriquecida con fitoesteroles para reducir los niveles de lipoproteínas aterogénicas en población pediátrica, por otra parte otro objetivo del estudio es analizar la influencia de diferentes polimorfismos genéticos en la respuesta a la leche enriquecida con los esteroles vegetales. Material y métodos: Ensayo clínico controlado, randomizado y doble ciego. Se administra leche desnatada enriquecida con esteroles vegetales. Los pacientes consumieron 700 ml de leche al día, lo cual contiene 2.24 g de esteroles vegetales al día durante 8 semanas. El grupo control consumió leche desnatada. Se incluyeron 67 pacientes pediátricos con edades comprendidas entre 5 y 12 años. A todos los participantes de este estudio que estuvieron en el grupo de tratamiento con esteroles vegetales se les ofreció participar en la segunda fase del estudio que incluía un estudio genético, en esta segunda fase del estudio participaron un total de 26 pacientes. Investigamos el impacto en el cholesterol total, LDL, HDL, cholesterol no HDL y triglicéridos del consumo de esteroles vegetales y su relación con los genes APOA5 C56G ser19trp (rs3135506) ( haplotipos CC, CG y GG ) , Prothrombin G20210A (rs1799963) ( haplotipos GG, GA y AA ), F5 arg506gln (rs6025) (haplotipos GG, GA y AA), MTHFR C677T (rs 1801133) ( haplotipos CC, CT y TT), LIPC C-514T (rs 1800588) (haplotipos CC, CT y TT), LPA I4399M (rs3798220) (haplotipos TT,TC y CC), PPAR-alpha L162V (rs1800206) (haplotipos CC, CG y GG). APOA5 – 1131T>C (rs662799)( haplotipos TT, TC y CC), APOE haplotipos APOE2/3/4 (rs429358) (haplotypes TT, TC y CC) y en ese mismo gen el (rs7412)( haplotipos TT, TC y CC). Todos estos genes están implicados en enfermedades cardiovasculares...
Dyslipidemia is a recognized cardiovascular risk factor. Objectives: To determine the efficacy of phytosterols enriched milk for reducing lipid levels in child population, in addition other objective is to analyze the influence of different polymorphisms in hypercholesterolemia patients following a treatment with plant sterols. Methods: Controlled, randomized, double-blind clinical trial. A sterol rich commercial milk was used. Subjects consumed daily 700 ml of milk which represents an amount of 2.24 g of sterols per day for eight weeks. The control group consumed skimmed milk. 67 pediatric patients included were in age between 5 and 12 years old. All participants of this first study who consumed the treatment milk and who agree to continue with the genetic variability study and whose parents or legal guardian accepted to sign up the informed consent has participated in the second branch of the study, a total of 26 patient. We investigate the impact in total Cholesterol, LDL, HDL, Cholesterol non HDL and TG responsiveness to Plant sterol consumption of SNPs of the genes: APOA5 C56G ser19trp (rs3135506) ( haplotypes CC, CG and GG ) , Prothrombin G20210A (rs1799963) ( haplotypes GG, GA and AA ), F5 arg506gln (rs6025) (haplotypes GG, GA and AA), MTHFR C677T (rs 1801133) ( haplotipes CC, CT and TT), LIPC C-514T (rs 1800588) ( haplotypes CC, CT and TT), LPA I4399M (rs3798220) (haplotypes TT,TC and CC), PPAR-alpha L162V (rs1800206) (haplotypes CC, CG and GG). APOA5 – 1131T>C (rs662799)( haplotypes TT, TC and CC), APOE haplotype APOE2/3/4 (rs429358) (haplotypes TT, TC and CC) and APOE haplotype APOE 2,3,4 ( rs7412)( haplotypeTT, TC and CC). All of this genes are implicated in risk of cardiovascular disease...
Dyslipidemia is a recognized cardiovascular risk factor. Objectives: To determine the efficacy of phytosterols enriched milk for reducing lipid levels in child population, in addition other objective is to analyze the influence of different polymorphisms in hypercholesterolemia patients following a treatment with plant sterols. Methods: Controlled, randomized, double-blind clinical trial. A sterol rich commercial milk was used. Subjects consumed daily 700 ml of milk which represents an amount of 2.24 g of sterols per day for eight weeks. The control group consumed skimmed milk. 67 pediatric patients included were in age between 5 and 12 years old. All participants of this first study who consumed the treatment milk and who agree to continue with the genetic variability study and whose parents or legal guardian accepted to sign up the informed consent has participated in the second branch of the study, a total of 26 patient. We investigate the impact in total Cholesterol, LDL, HDL, Cholesterol non HDL and TG responsiveness to Plant sterol consumption of SNPs of the genes: APOA5 C56G ser19trp (rs3135506) ( haplotypes CC, CG and GG ) , Prothrombin G20210A (rs1799963) ( haplotypes GG, GA and AA ), F5 arg506gln (rs6025) (haplotypes GG, GA and AA), MTHFR C677T (rs 1801133) ( haplotipes CC, CT and TT), LIPC C-514T (rs 1800588) ( haplotypes CC, CT and TT), LPA I4399M (rs3798220) (haplotypes TT,TC and CC), PPAR-alpha L162V (rs1800206) (haplotypes CC, CG and GG). APOA5 – 1131T>C (rs662799)( haplotypes TT, TC and CC), APOE haplotype APOE2/3/4 (rs429358) (haplotypes TT, TC and CC) and APOE haplotype APOE 2,3,4 ( rs7412)( haplotypeTT, TC and CC). All of this genes are implicated in risk of cardiovascular disease...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina Preventiva, Salud Pública e Historia de la Ciencia, leída el 03/05/2017