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Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis

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Nieves Moreno, María and Martínez de la Casa, Jose Maria and Morales Fernández, Laura and Sánchez Jean, Rubén and Sáenz Francés, Federico and García Feijoo, Julián (2018) Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis. PLoS ONE, 13 (e01941). ISSN 1932-6203

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Official URL: https://doi.org/10.1371/journal.pone.0194169




Abstract

Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex.
Design: Cross-sectional, observational study.
Methods: The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years. In one randomly selected eye of each participant the volume and mean thicknesses of the different macular layers were measured by SD-OCT using the instrument's macular segmentation software.
Main outcome measures: Volume and mean thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigmentary epithelium (RPE) and photoreceptor layer (PR).
Results: Retinal thickness was reduced by 0.24 μm for every one year of age. Age adjusted linear regression analysis revealed mean GCL, IPL, ONL and PR thickness reductions and a mean OPL thickness increase with age. Women had significantly lower mean GCL, IPL, INL, ONL and PR thicknesses and volumes and a significantly greater mRNFL volume than men.
Conclusion: The thickness of most retinal layers varies both with age and according to sex. Longitudinal studies are needed to determine the rate of layer thinning produced with age.


Item Type:Article
Additional Information:

Received: December 7, 2017; Accepted: February 26, 2018; Published: March 9, 2018

Uncontrolled Keywords:Eyes; Tomography; Retina; Nerve fibers; Epithelium; Photoreceptors; Ganglion cells; OCT
Subjects:Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine
Medical sciences > Medicine > Ophtalmology
ID Code:47055
Deposited On:06 Apr 2018 08:02
Last Modified:06 Apr 2018 08:02

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