Publication: Índice tobillo-brazo como método de valoración de riesgo vascular en pacientes con enfermedad renal crónica
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2018-04-06
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Universidad Complutense de Madrid
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Abstract
La enfermedad vascular tiene un gran impacto sobre el pronóstico de los pacientes con enfermedad renal crónica, siendo la primera causa de mortalidad independientemente del grado de disfunción renal. Las razones que explican la mayor incidencia de eventos vasculares son la mayor prevalencia de comorbilidades coexistentes y procesos patogénicos de la propia enfermedad renal. Por ello, resulta imprescindible encontrar métodos que permitan una mejor estratificación del riesgo vascular de los pacientes renales. Se han estudiado muchos biomarcadores y técnicas, pero la mayoría no están al alcance de la práctica clínica diaria. El índice tobillo-brazo es una herramienta sencilla, económica, rápida y fiable para evaluar la salud vascular y determinar de forma más precisa el riesgo de eventos a medio y largo plazo. Con ello, se podrán enfocar los esfuerzos terapéuticos en aquellos pacientes con mayor probabilidad de sufrir complicaciones vasculares...
Vascular disease has an indisputable effect on the prognosis of patients with chronic kidney disease. It is the first cause of mortality, regardless of the severity of renal dysfunction. There are various reasons that explain a higher rate of vascular events in renal patients, including a higher prevalence of coexisting comorbidities, as well as pathogenic processes specifically related to renal insufficiency. Hence, it is mandatory to find methods that aid a better vascular risk stratification of renal patients. Many biomarkers and techniques have been and are under evaluation, but most of them are unavailable in daily clinical practice. Ankle-brachial index is a simple, inexpensive, quick and reliable tool to study vascular disease and to accurately determine vascular risk in the medium and long terms. This way, therapeutical efforts can be focused on those patients with higher probabilities of suffering vascular complications...
Vascular disease has an indisputable effect on the prognosis of patients with chronic kidney disease. It is the first cause of mortality, regardless of the severity of renal dysfunction. There are various reasons that explain a higher rate of vascular events in renal patients, including a higher prevalence of coexisting comorbidities, as well as pathogenic processes specifically related to renal insufficiency. Hence, it is mandatory to find methods that aid a better vascular risk stratification of renal patients. Many biomarkers and techniques have been and are under evaluation, but most of them are unavailable in daily clinical practice. Ankle-brachial index is a simple, inexpensive, quick and reliable tool to study vascular disease and to accurately determine vascular risk in the medium and long terms. This way, therapeutical efforts can be focused on those patients with higher probabilities of suffering vascular complications...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 26-06-2017