Publication: Modelos matemáticos de pronóstico para cáncer de cérvix localmente avanzado. Validación externa de los modelos existentes
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2018-04-11
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Universidad Complutense de Madrid
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Abstract
Los modelos de pronóstico son procedimientos matemáticos capaces de obtener la probabilidad de riesgo absoluta para un desenlace específico de un individuo, basado en las características biográficas, biológicas, terapéuticas y clínicas. Implican el uso de una metodología singular y compleja. Un paso decisivo para su utilización beneficiosa es realizar una correcta validación. En la actualidad, existen múltiples modelos de pronóstico desarrollados para el cáncer de cérvix localmente avanzado (CCLA), estadio IB2 a IVA de la Federación Internacional de Ginecología y Obstetricia (FIGO). No todos los modelos de pronóstico están validados externamente, condición necesaria para su utilización clínica. 1.3 Objetivos. Validar externamente los modelos de pronóstico para el CCLA desarrollados en pacientes tratadas con quimio-radioterapia concurrente en una cohorte independiente. Identificar y contrastar criterios de buen uso de los procedimientos de investigación pronóstica y validación de modelos predictivos...
A prognostic model is a mathematical procedure that estimates the absolute probability of risk for a specific outcome in an individual at a given time by combining different types of information (predictors) on the patient. The prognostic models involve the use of unique and complex methodology. A decisive step to be useful is a correct validation. Currently, multiple prognostic models have been developed for Locally Advanced Cervical Cancer (LACC), International Federation of Gynecology and Obstetrics (FIGO) stage between IB2 and IVA. However, few prognostic models described to date have been independently validated by other researchers and/or elsewhere, which is a necessary condition for their clinical use. 2.3 Objectives. To externally validate the prognostic models for LACC and who were treated with concurrent chemoradiotherapy in an independient cohort. To identify and contrast good use criteria of procedures of prognostic research and validation of predictive models...
A prognostic model is a mathematical procedure that estimates the absolute probability of risk for a specific outcome in an individual at a given time by combining different types of information (predictors) on the patient. The prognostic models involve the use of unique and complex methodology. A decisive step to be useful is a correct validation. Currently, multiple prognostic models have been developed for Locally Advanced Cervical Cancer (LACC), International Federation of Gynecology and Obstetrics (FIGO) stage between IB2 and IVA. However, few prognostic models described to date have been independently validated by other researchers and/or elsewhere, which is a necessary condition for their clinical use. 2.3 Objectives. To externally validate the prognostic models for LACC and who were treated with concurrent chemoradiotherapy in an independient cohort. To identify and contrast good use criteria of procedures of prognostic research and validation of predictive models...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 28-03-2017