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From Proof-of-Concept Material to PEGylated and Modularly Targeted Ultrasound-Responsive Mesoporous Silica Nanoparticles

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Paris, J.L. and Villaverde, Gonzalo and Cabañas Criado, Maria Victoria and Manzano García, Miguel and Vallet Regí, María (2018) From Proof-of-Concept Material to PEGylated and Modularly Targeted Ultrasound-Responsive Mesoporous Silica Nanoparticles. Journal of Materials Chemistry B . ISSN 2050-750X

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Abstract

In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategies necessary to afford a modular nanocarrier starting from a proof-of-concept material presented in previous work. This functional ultrasound-responsive material can be adapted to different specific pathological conditions by carefully choosing the appropriate targeting moieties. The new ultrasound responsive material is able to target HeLa cells when conjugated with biotin or an RGD peptide. Ultrasound-responsive cytotoxicity towards cancer cells of doxorubicinloaded nanoparticles is demonstrated in an in vitro cytotoxicity assay.


Item Type:Article
Additional Information:

RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente)
ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente)
RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)
ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:47146
Deposited On:18 Apr 2018 09:23
Last Modified:12 Apr 2019 23:01

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