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Removal of the blue component of light significantly decreases retinal damage after high intensity exposure

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Vicente-Tejedor, Javier and Marchena, Miguel and Ramírez, Laura and García Ayuso, Diego and Gómez Vicente, Violeta and Sánchez Ramos, Celia and Villa Polo, Pedro de la and Germain, Francisco (2018) Removal of the blue component of light significantly decreases retinal damage after high intensity exposure. PLoS ONE, 13 (3). e0194218. ISSN 1932-6203

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Official URL: https://doi.org/10.1371/journal.pone.0194218




Abstract

Light causes damage to the retina (phototoxicity) and decreases photoreceptor responses to light. The most harmful component of visible light is the blue wavelength (400–500 nm). Different filters have been tested, but so far all of them allow passing a lot of this wavelength (70%). The aim of this work has been to prove that a filter that removes 94% of the blue component may protect the function and morphology of the retina significantly. Three experimental groups were designed. The first group was unexposed to light, the second one was exposed and the third one was exposed and protected by a blue-blocking filter. Light damage was induced in young albino mice (p30) by exposing them to white light of high intensity (5,000 lux) continuously for 7 days. Short wavelength light filters were used for light protection. The blue component was removed (94%) from the light source by our filter. Electroretinographical recordings were performed before and after light damage. Changes in retinal structure were studied using immunohistochemistry, and TUNEL labeling. Also, cells in the outer nuclear layer were counted and compared among the three different groups. Functional visual responses were significantly more conserved in protected animals (with the blue-blocking filter) than in unprotected animals. Also, retinal structure was better kept and photoreceptor survival was greater in protected animals, these differences were significant in central areas of the retina. Still, functional and morphological responses were significantly lower in protected than in unexposed groups. In conclusion, this blue-blocking filter decreases significantly photoreceptor damage after exposure to high intensity light. Actually, our eyes are exposed for a very long time to high levels of blue light (screens, artificial light LED, neons…). The potential damage caused by blue light can be palliated.


Item Type:Article
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En O.A. en la web del editor.
Received: August 9, 2017; Accepted: February 27, 2018; Published: March 15, 2018.
© 2018 Vicente-Tejedor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Uncontrolled Keywords:Photoreceptors; Retina; Light; Apoptosis; Eyes; Chromophores; White light; Retinal damage
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Physiological optics
ID Code:47172
Deposited On:19 Apr 2018 12:54
Last Modified:20 Apr 2018 07:49

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