Publication: Influencia pronóstica de la determinación precoz del aclaramiento del verde de indocianina en la evolución después del trasplante hepático
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2018-04-18
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Universidad Complutense de Madrid
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Abstract
El trasplante hepático (TH) es la mejor opción terapéutica para pacientes con enfermedad hepática terminal. La evolución precoz tras el trasplante es una cuestión fundamental que depende de las características del donante, del receptor, del procedimiento quirúrgico y de la asistencia intra y postoperatoria. Sin embargo, en la actualidad no existen herramientas validadas capaces de predecir de forma precoz la mortalidad a corto plazo o la necesidad de retrasplante urgente en los receptores de un TH. La posibilidad de identificar de forma precoz aquellos pacientes en mayor riesgo de muerte y retrasplante tempranos sería ideal para su correcto manejo en el postoperatorio inmediato. El aclaramiento del verde de indocianina, un colorante hidrosoluble y no tóxico, se utiliza para medir la función y el flujo sanguíneo hepático. Se puede medir la tasa de desaparición plasmática del verde de indocianina (PDR) de forma no invasiva y a pie de cama por espectrofotometría transcutánea pulsátil, demostrando una adecuada correlación con la medida invasiva...
Liver Transplantation (LT) is the best therapeutic solution for patients with end-stage liver disease. Short-term outcome after LT is a critical issue that depends on donor, recipient and transplant procedure characteristics. It can also be affected by intraoperative and immediate postoperative care. To date, no validated predictive tool has been established for early death or retransplantation after LT. The possibility of prompt identification of patients at higher risk of early death or retransplantation could provide invaluable help for their proper management in the immediate post-operative period. Indocyanine green (ICG) clearance, a water-soluble non-toxic dye, is used to assess liver blood flow and function. Plasma disappearance rate of ICG (PDR) can be measured by a non-invasive and point-of-care technique based on transcutaneous pulse spectophotometry...
Liver Transplantation (LT) is the best therapeutic solution for patients with end-stage liver disease. Short-term outcome after LT is a critical issue that depends on donor, recipient and transplant procedure characteristics. It can also be affected by intraoperative and immediate postoperative care. To date, no validated predictive tool has been established for early death or retransplantation after LT. The possibility of prompt identification of patients at higher risk of early death or retransplantation could provide invaluable help for their proper management in the immediate post-operative period. Indocyanine green (ICG) clearance, a water-soluble non-toxic dye, is used to assess liver blood flow and function. Plasma disappearance rate of ICG (PDR) can be measured by a non-invasive and point-of-care technique based on transcutaneous pulse spectophotometry...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 10-05-2017