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Diquafosol Delivery from Silicone Hydrogel Contact Lenses: Improved Effect on Tear Secretion

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Dominguez Godínez, Carmen Olalla and Carracedo Rodríguez, Juan Gonzalo and Pintor, Jesús (2018) Diquafosol Delivery from Silicone Hydrogel Contact Lenses: Improved Effect on Tear Secretion. Journal of Ocular Pharmacology and Therapeutics, 34 (1-2). ISSN 1080-7683

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Official URL: https://doi.org/10.1089/jop.2016.0193




Abstract

Purpose: The aim of this study was to evaluate the ability to uptake and to deliver diquafosol from commercial contact lenses (CLs) and its effect on tear secretion.
Methods: For both in vitro and in vivo experiments, two commercial silicone hydrogel (Si-Hy) CLs (comfilcon A and balafilcon A) were used. The CLs were soaked overnight for 12 h in diquafosol solution and control CLs were soaked in saline solution (NaCl 0.9%). The CLs were introduced into a new well container with 1 mL of saline solution, and aliquots of 100 μL were extracted at different times during a period of 6 h to measure the diquafosol release. For in vivo experiments, nine male New Zealand white rabbits were used. CLs soaked in diquafosol were inserted in the eye and compared with control CLs and diquafosol topical instillation. Schirmer's tests were performed to evaluate tear secretion and diquafosol release at different times during the 6-h period.
Results: For in vitro experiments, the largest amount of diquafosol was released during the first 24 h for both CL materials under study, without statistical differences between them (P < 0.05). The topical application showed the maximum release at 1 min after instillation, meanwhile the release from both CL materials was at 30 min of insertion. The effect on tear secretion was higher with CL delivery compared with topical instillation (P < 0.05), being 300 min for both CLs and 90 min for topical application.
Conclusion: The use of CLs increases the residence time of diquafosol on the ocular surface with a concomitant enhancement in tear secretion during longer periods.


Item Type:Article
Additional Information:

Received 5 January 2017; Accepted 28 April 2017; Published online 1 March 2018; Published in print 1 March 2018

Uncontrolled Keywords:Diquafosol; Contact lens; Delivery; P2Y2 receptors; Dinucleoside polyphosphate; Up4U
Subjects:Sciences > Chemistry > Biochemistry
Medical sciences > Optics > Contact lenses
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Optical materials
ID Code:47331
Deposited On:26 Apr 2018 08:06
Last Modified:27 Apr 2018 08:34

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