Universidad Complutense de Madrid
E-Prints Complutense

Nanotechnological Strategies for Protein Delivery

Impacto

Downloads

Downloads per month over past year

Villegas Díaz, María Rocío and Baeza, Alejandro and Vallet Regí, María (2018) Nanotechnological Strategies for Protein Delivery. Molecules, 23 (5). ISSN 1420-3049

[img]
Preview
PDF
1MB

Official URL: http://www.mdpi.com/1420-3049/23/5/1008




Abstract

The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation.


Item Type:Article
Additional Information:

RESEARCHER ID V-7077-2017 (María Rocío Villegas Díaz)
ORCID 0000-0002-1297-2355 (María Rocío Villegas Díaz)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-2026-6266 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Protein delivery system, PEGylation, Liposomes, Nanoparticles, Polymeric nanocapsules, Vprotein therapy
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:47336
Deposited On:09 May 2018 11:07
Last Modified:09 May 2018 14:48

Origin of downloads

Repository Staff Only: item control page