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Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three

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Gaya, Pilar and Sánchez-Jiménez, Abel and Peirotén, Angela and Medina, Margarita and Landete, José María (2018) Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three. International Journal of Food Sciences and Nutrition, 69 (3). pp. 334-343. ISSN 0963-7486, ESSN: 1465-3478

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Official URL: https://www.tandfonline.com/doi/full/10.1080/09637486.2017.1353955



Abstract

Phytoestrogens are plant-derived polyphenols with structural and functional similarities to mammalian oestrogens. The aim of this work was to study the metabolism of phytoestrogens by children’s intestinal microbiota and to compare it with previous results in adults. Faecal samples of 24 healthy children were subjected to phytoestrogen fermentation assay. Only one child produced equol, while O-desmethylangolensin was found in all. Urolithin production was detected in 14 children and enterolactone in 10. Further comparison with the metabolism of phytoestrogens by adult intestinal microbiota reflected that glycitein, dihydrogenistein, urolithins D and E, enterolactone, secoisolariciresinol and arctigenin were the most important metabolites differentiating between adult and child microbial gut metabolism. Although the child intestinal microbiota showed the ability to metabolise isoflavones, ellagitannins and lignans to a certain extent, it generally showed a reduced metabolism of phytoestrogens, with a lack of 5-hydroxy equol and enterodiol, and less urolithins and enterolactone producers.


Item Type:Article
Uncontrolled Keywords:Isoflavones; Ellagitannins; Lignans; Children; Microbial metabolism
Subjects:Medical sciences > Biology > Microbiology
ID Code:47354
Deposited On:27 Apr 2018 09:53
Last Modified:10 Dec 2018 15:25

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