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Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

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Guisasola, Eduardo and Baeza, Alejandro and Asin, Laura and De la Fuente, J. M. and Vallet Regí, María (2018) Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles. Small Methods . ISSN 2366-9608 (In Press)

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/smtd.201800007




Abstract

Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic- and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscale heating in combination with chemotherapy through drug-delivery devices to effectively kill cancer cells. In this way, the nanoparticles act as heating sources or “hot spots,” which can trigger cellular responses in the absence of a global temperature rise, making the tumor cells more sensitive to chemotherapeutics. The fabrication of optical and magnetic drug-delivery devices, the heating mechanisms, and their applications in tumor treatment are also summarized.


Item Type:Article
Additional Information:

RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)
ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Subjects:Sciences > Chemistry > Materials
Medical sciences > Medicine > Oncology
Medical sciences > Pharmacy > Inorganic chemistry
Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:47380
Deposited On:09 May 2018 12:22
Last Modified:09 May 2018 14:46

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