Universidad Complutense de Madrid
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Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

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Guisasola, Eduardo y Baeza, Alejandro y Asin, Laura y De la Fuente, J. M. y Vallet Regí, María (2018) Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles. Small Methods . ISSN 2366-9608 (En prensa)

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URL Oficial: https://onlinelibrary.wiley.com/doi/10.1002/smtd.201800007




Resumen

Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic- and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscale heating in combination with chemotherapy through drug-delivery devices to effectively kill cancer cells. In this way, the nanoparticles act as heating sources or “hot spots,” which can trigger cellular responses in the absence of a global temperature rise, making the tumor cells more sensitive to chemotherapeutics. The fabrication of optical and magnetic drug-delivery devices, the heating mechanisms, and their applications in tumor treatment are also summarized.


Tipo de documento:Artículo
Información Adicional:

RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)
ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Materias:Ciencias > Química > Materiales
Ciencias Biomédicas > Medicina > Oncología
Ciencias Biomédicas > Farmacia > Química inorgánica
Ciencias Biomédicas > Farmacia > Tecnología farmaceútica
Código ID:47380
Depositado:09 May 2018 12:22
Última Modificación:09 May 2018 14:46

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