Universidad Complutense de Madrid
E-Prints Complutense

Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation



Último año

Kurzbauer, Marie-Therese y Pradillo Orellana, Mónica y Kerzendorfer, Claudia y Sims, Jason y Ladurner, Rene y Oliver, Cecilia y Janisiw, Michael Peter y Mosiolek, Magdalena y Schweizer, Dieter y Copenhaver, Gregory P. y Schlögelhofer, Peter (2018) Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation. Plant Cell, 30 (2). pp. 415-428. ISSN 1040-4651, ESSN: 1532-298X

[img] PDF
Restringido a Sólo personal autorizado del repositorio


URL Oficial: http://www.plantcell.org/content/30/2/415


Fanconi anemia (FA) is a human autosomal recessive disorder characterized by chromosomal instability, developmental pathologies, predisposition to cancer, and reduced fertility. So far, 19 genes have been implicated in FA, most of them involved in DNA repair. Some are conserved across higher eukaryotes, including plants. The Arabidopsis thaliana genome encodes a homolog of the Fanconi anemia D2 gene (FANCD2) whose function in DNA repair is not yet fully understood. Here, we provide evidence that AtFANCD2 is required for meiotic homologous recombination. Meiosis is a specialized cell division that ensures reduction of genomic content by half and DNA exchange between homologous chromosomes via crossovers (COs) prior to gamete formation. In plants, a mutation in AtFANCD2 results in a 14% reduction of CO numbers. Genetic analysis demonstrated that AtFANCD2 acts in parallel to both MUTS HOMOLOG4 (AtMSH4), known for its role in promoting interfering COs and MMS AND UV SENSITIVE81 (AtMUS81), known for its role in the formation of noninterfering COs. AtFANCD2 promotes noninterfering COs in a MUS81-independent manner and is therefore part of an uncharted meiotic CO-promoting mechanism, in addition to those described previously.

Tipo de documento:Artículo
Palabras clave:Arabidopsis thaliana; Meiosis; Fanconi anemia
Materias:Ciencias Biomédicas > Medicina > Hematología
Ciencias Biomédicas > Biología > Botánica
Ciencias Biomédicas > Biología > Genética
Código ID:47513
Depositado:11 May 2018 11:05
Última Modificación:10 Dic 2018 15:30

Descargas en el último año

Sólo personal del repositorio: página de control del artículo