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Probiotics in digestive, emotional, and pain-related disorders

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Roman, Pablo and Abalo, Raquel and Marco López, Eva María and Cardona, Diana (2018) Probiotics in digestive, emotional, and pain-related disorders. Behavioural Pharmacology, 29 (2-3). pp. 103-119. ISSN 0955-8810, ESSN: 1473-5849

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Official URL: https://journals.lww.com/behaviouralpharm/Abstract/2018/04000/Probiotics_in_digestive,_emotional,_and.3.aspx



Abstract

In recent years, interest in the relationship between gut microbiota and disease states has grown considerably. Indeed, several strategies have been employed to modify the microbiome through the administration of different diets, by the administration of antibiotics or probiotics, or even by transplantation of feces. In the present manuscript, we focus specifically on the potential application of probiotics, which seem to be a safe strategy, in the management of digestive, pain, and emotional disorders. We present evidence from animal models and human studies, notwithstanding that translation to clinic still deserves further investigation. The microbiome influences gut functions as well as neurological activity by a variety of mechanisms, which are also discussed. The design and performance of larger trials is urgently needed to verify whether these new strategies might be useful not only for the treatment of disorders affecting the gastrointestinal tract but also in the management of emotional and pain disorders not directly related to the gut.


Item Type:Article
Uncontrolled Keywords:Animal models; Emotion; Gastrointestinal disorders; Gut microbiota; Human studies; Pain; Probiotics
Subjects:Medical sciences > Medicine > Gastroenterology and Hepatology
Medical sciences > Biology > Microbiology
ID Code:47617
Deposited On:18 May 2018 11:37
Last Modified:18 May 2018 11:37

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