Universidad Complutense de Madrid
E-Prints Complutense

The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.



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Gómez-Cerezo, Natividad y Verron, E y Montouillout, V y Fayon, F y Lagadec, P y Bouler, J.M. y Bujoli, B y Arcos Navarrete, Daniel y Vallet Regí, María (2018) The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses. Acta Biomaterialia, 76 . pp. 333-343. ISSN 1742-7061 (En prensa)

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URL Oficial: https://www.journals.elsevier.com/acta-biomaterialia

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Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been
characterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios.

Tipo de documento:Artículo
Información Adicional:

RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Palabras clave:Gallium, Mesoporous bioactive glasses, Osteoblast, Osteoclast, Osteoporosis
Materias:Ciencias > Química > Materiales
Ciencias Biomédicas > Farmacia > Química inorgánica
Código ID:48536
Depositado:20 Aug 2018 12:21
Última Modificación:21 Aug 2018 08:07

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