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Osteogenic Effect of ZnO-Mesoporous Glasses loaded with Osteostatin

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Pérez, Rebeca and Sánchez-Salcedo, Sandra and Lozano Borregón, Daniel and Heras, Clara and Esbrit, Pedro and Vallet Regí, María and Salinas Sánchez, Antonio J. (2018) Osteogenic Effect of ZnO-Mesoporous Glasses loaded with Osteostatin. Nanomaterials, 8 (8). p. 592. ISSN 2079-4991

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Official URL: http://www.mdpi.com/journal/nanomaterials




Abstract

Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties determine high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with composition, in mol-%, 80%SiO2–15%CaO–5%P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnation with osteostatin, a C-terminal peptide from parathyroid hormone-related protein (PTHrP107-111). Zn2+ ions were included in the glass for their bone growth stimulator properties, whereas osteostatin was added by its osteogenic properties. Glasses were characterized, and their cytocompatibility investigated in pre-osteoblastic MC3T3-E1 cell cultures. The simultaneous additions of osteostatin and Zn2+ ions provoked enhanced MC3T3-E1 cell viability and higher differentiation capacity, compared with either raw BL or MBGs supplemented only with osteostatin or Zn2+. These in vitro results show that osteostatin enhances the osteogenic effect of Zn2+-enriched glasses, suggesting the potential of this combined approach in bone tissue engineering applications.


Item Type:Article
Additional Information:

RESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo)
ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)
RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)
ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID M-3316-2014 (Antonio Salinas Sánchez)
ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)

Uncontrolled Keywords:Mesoporous glasses; ZnO-additions; Osteostatin loading; Osteosteoblast cell cultures; Osteogenic effect
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:49013
Deposited On:20 Sep 2018 09:16
Last Modified:20 Sep 2018 11:42

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