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Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability

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Cabañas Criado, Victoria and Lozano Borregón, Daniel and Torres-Pardo, A. and Sobrino, C. and González-Calvet, J. and Arcos Navarrete, Daniel and Vallet Regí, María (2018) Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability. Materials Chemistry and Physics, 220 . pp. 260-269. ISSN 0254-0584

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Official URL: http://www.speciation.net/Database/Companies/Elsevier/Elsevier-Science-SA-Lausanne-;i212a1879




Abstract

Aminopropyl modified mesoporous SiO2 nanoparticles, MCM-41 type, have been synthesized by the co-condensation method from tetraethylorthosilicate (TEOS) and aminopropyltriethoxysilane (APTES). By means of modifying TEOS/APTES ratio we have carried out an in-depth characterization of the nanoparticles as a function of APTES content. Surface charge and nanoparticles morphology were strongly influenced by the amount of APTES and particles changed from hexagonal to bean-like morphology insofar APTES increased. Besides, the porous structure was also affected, showing a contraction of the lattice parameter and pore size, while increasing the wall thickness. These results bring about new insights about the nanoparticles formation during the co-condensation process. The model proposed herein considers that different interactions stablished between TEOS and APTES with the structure directing agent have consequences on pore size, wall thickness and particle morphology. Finally, APTES is an excellent linker to covalently attach active targeting agents such as folate groups. We have hypothesized that APTES could also play a role in the biological behavior of the nanoparticles. So, the internalization efficiency of the nanoparticles has been tested with cancerous LNCaP and non-cancerous preosteoblast-like MC3T3-E1 cells. The results indicate a cooperative effect between aminopropylsilane presence and folic acid, only for the cancerous LNCaP cell line.


Item Type:Article
Additional Information:

RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)
ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)
ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)
RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous nanoparticles, co-condensation, APTES, folic acid, active targeting
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:49059
Deposited On:20 Sep 2018 12:11
Last Modified:21 Sep 2018 07:34

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