Publication: Nanomateriales híbridos para el diseño de biosensores enzimáticos electroquímicos
Loading...
Official URL
Full text at PDC
Publication Date
2018-09-19
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
En la actualidad, la ingeniería de nanomateriales está considerada como una de lastecnologías emergentes más importantes, la cual deberá impactar significativamente en lacalidad de la ciencia y la sociedad en los próximos años. Esta rama científica ha abierto laposibilidad de diseñar nanomateriales avanzados a medida, los cuales presentanpropiedades físico-químicas y funcionales concretas, logradas mediante la manipulaciónracional de sus composiciones químicas, morfología, tamaño y derivatización superficial.Estos novedosos nanomateriales permitirán la producción de una nueva generación debiomateriales, sistemas de computación, pinturas y otros recubrimientos protectores,sistemas de liberación controlada de fármacos, ropas y accesorios inteligentes, dispositivoselectrónicos y sistemas sensores de dimensiones nanométricas y propiedades mejoradas.En este contexto, el objetivo principal de la ingeniería de nanomateriales es elestablecimiento de estrategias originales para la preparación racional de nanoestructurascon propiedades fisicoquímicas y funciones únicas y bien definidas. En este sentido, eldesarrollo de nuevos nanomateriales funcionales para su utilización en aplicacionesbiológicas emergentes es un tema de investigación de plena actualidad que recibe un interésmuy especial dentro de la comunidad científica internacional.Una de las estrategias más efectivas para la preparación de nanoestructuras a medida esla funcionalización con otros materiales moleculares o nanométricos. Estos materiales debenproporcionar grupos funcionales específicos para garantizar una alta biocompatibilidad,hidrofilicidad y capacidad para la inmovilización estable de macromoléculas bioactivas. Apartir de esta metodología se obtienen nanomateriales híbridos en los cuales la estructura,el nivel de organización y las propiedades nuevas y sinérgicas están moduladas por lanaturaleza química y la arquitectura molecular de los componentes individuales...
Nowadays, nanomaterials engineering is recognized as a top emerging technology thatwill have a major impact on the quality of science and society over the next years. Thisscientific field has already opened the possibility to tailor-made design advancednanomaterials with desired physicochemical and functional properties, based on the rationalmanipulation of their chemical composition, morphology, size and surface derivatization.These novel nanomaterials will allow the production of the next generation ofbiomaterials, computing systems, protective coatings, drug-delivery systems, electronicdevices, functional textiles and wearable devices, and sensor systems with improvedproperties and nanometric dimensions.In this context, the ultimate goal for nanomaterials engineering is the establishment oforiginal synthetic strategies for the rational preparation of nanosized structures with uniqueand well-defined characteristics. Special attention is currently devoted to the design of novelfunctional nanomaterials for emerging biologically driven applications. These materialsshould be provided with specific chemical functionalities to ensure high biocompatibility,hydrophilicity and capacity for the stable immobilization of biologically-activemacromolecules.A rational strategy to prepare these novel nanostructures is the tailored functionalizationwith other molecular or nanosized materials to yield hybrid derivatives, in which theresulting structure, degree of organization and therefore the synergistic and novelproperties are ruled by the chemical nature and molecular architecture of the individualcomponents. In particular, considerable interest is currently devoted to the preparation ofconductive hybrid nanomaterials with improved biocompatibility for proteins, nucleic acids,cells and tissues oriented to the fabrication of bioelectronics, biocomputing and biosensingsystems...
Nowadays, nanomaterials engineering is recognized as a top emerging technology thatwill have a major impact on the quality of science and society over the next years. Thisscientific field has already opened the possibility to tailor-made design advancednanomaterials with desired physicochemical and functional properties, based on the rationalmanipulation of their chemical composition, morphology, size and surface derivatization.These novel nanomaterials will allow the production of the next generation ofbiomaterials, computing systems, protective coatings, drug-delivery systems, electronicdevices, functional textiles and wearable devices, and sensor systems with improvedproperties and nanometric dimensions.In this context, the ultimate goal for nanomaterials engineering is the establishment oforiginal synthetic strategies for the rational preparation of nanosized structures with uniqueand well-defined characteristics. Special attention is currently devoted to the design of novelfunctional nanomaterials for emerging biologically driven applications. These materialsshould be provided with specific chemical functionalities to ensure high biocompatibility,hydrophilicity and capacity for the stable immobilization of biologically-activemacromolecules.A rational strategy to prepare these novel nanostructures is the tailored functionalizationwith other molecular or nanosized materials to yield hybrid derivatives, in which theresulting structure, degree of organization and therefore the synergistic and novelproperties are ruled by the chemical nature and molecular architecture of the individualcomponents. In particular, considerable interest is currently devoted to the preparation ofconductive hybrid nanomaterials with improved biocompatibility for proteins, nucleic acids,cells and tissues oriented to the fabrication of bioelectronics, biocomputing and biosensingsystems...
Description
Tesis de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, Departamento de Química Analítica, leída el 12-06-2017