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Targeted Chemo‐Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment

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Villaverde, Gonzalo and Gómez-Graña, Sergio and Guisasola, Eduardo and García, Isabel and Hanske, Cristoph and Liz-Marzan, Luis M and Baeza, Alejandro and Vallet Regí, María (2018) Targeted Chemo‐Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment. Particle & Particle Systems Characterization . p. 1800148. ISSN 0934-0866

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Official URL: https://onlinelibrary.wiley.com/journal/10974652




Abstract

Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. However, melanoma is highly resistant to cytotoxicity in its metastatic form. In this context, we propose a therapeutic strategy based on a targeted chemo-photothermal nanotransporter for cytotoxic compounds. This approach comprises the use of core-multishell gold nanorods, coated with mesoporous silica and further covered with a thermosensitive polymer, which is vectorized for selective internalization in melanoma cells. The proposed nanoformulation is capable of releasing the transported cytotoxic compounds on demand, in response to near-IR irradiation, with high selectivity and efficacy against malignant cells, even at low concentrations, thereby providing a new tool against melanoma disease.


Item Type:Article
Additional Information:

RESEARCHER ID L-2250-2014 (Gonzalo Villaverde Cantizano)
ORCID 0000-0003-2065-0417 (Gonzalo Villaverde Cantizano)
RESEARCHER ID G-7562-2016 (Sergio Gómez Graña)
ORCID 0000-0002-7736-051X (Sergio Gómez Graña)
RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)
ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-2026-6266 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Melanoma, NAPamide, Photothermal therapy
Subjects:Sciences > Chemistry > Materials
ID Code:49275
Deposited On:26 Sep 2018 07:43
Last Modified:31 May 2019 23:01

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