Universidad Complutense de Madrid
E-Prints Complutense

Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.

Impacto

Downloads

Downloads per month over past year



Castillo, Rafael R. and Lozano Borregón, Daniel and Vallet Regí, María (2018) Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery. Bioconjugate Chemistry . ISSN 1043-1802 (In Press)

[img]
Preview
PDF
2MB

Official URL: https://pubs.acs.org/action/showPublications?display=journals




Abstract

ABSTRACT: Despite encapsulation of drugs claim to improve
the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, there has been designed a two-drug delivery system with dual cell-organelle targeting based on Mesoporous Silica Nanoparticles, known to be able to host drugs within their pores. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug delivery nanodevices against difficult-to-treat cancers.


Item Type:Article
Additional Information:

RESEARCHER ID L-2854-2014 (Rafael Castillo Romero)
ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)
RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)
ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:49370
Deposited On:03 Oct 2018 10:47
Last Modified:02 Oct 2019 23:01

Origin of downloads

Repository Staff Only: item control page