Publication: Sistemas de liberación controlada de medicamentos. Aplicaciones biomédicas.
Loading...
Official URL
Full text at PDC
Publication Date
2016-02
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Citations
Exportar
Abstract
Las Formas Farmacéuticas de Liberación Modificada (FFLM) son aquellas en las que la velocidad y el lugar de liberación de la sustancia o sustancias activas, es diferente al de la forma farmacéutica de liberación convencional administrada por la misma vía. Los avances biomédicos de los últimos años, han hecho posible investigar nuevos sistemas de liberación modificada basados en polímeros inteligentes y sistemas poliméricos de targeting, como es el caso de los hidrogeles funcionalizados con aptámeros. En el presente trabajo se realiza una revisión bibliográfica para conocer el uso de estos sistemas en el tratamiento de distintas patologías y las ventajas que presentan. Los resultados muestran la capacidad de los hidrogeles funcionalizados con aptámeros para liberar los fármacos de manera controlada y dirigida al lugar de acción, gracias a su especificidad y afinidad con la molécula diana.
Pharmaceutical Dosage Forms for controlled release of therapeutic agents are those which speed and drug delivery site are different from the native dosage form. Advances in biomedicine over the last few years have led to investigate new controlled drug delivery systems based on smart polymers and targeted delivery, such as aptamers functionalized hydrogels. In the present report, a bibliographical research on the use of these systems in a variety of diseases has been done, as well as on its advantages. In the light of the results the aptamers functionalized hydrogels ability is demonstrated. Therefore these systems can control the release of drugs at a target site with a desired rate because of its specifity and affinity with the target.
Pharmaceutical Dosage Forms for controlled release of therapeutic agents are those which speed and drug delivery site are different from the native dosage form. Advances in biomedicine over the last few years have led to investigate new controlled drug delivery systems based on smart polymers and targeted delivery, such as aptamers functionalized hydrogels. In the present report, a bibliographical research on the use of these systems in a variety of diseases has been done, as well as on its advantages. In the light of the results the aptamers functionalized hydrogels ability is demonstrated. Therefore these systems can control the release of drugs at a target site with a desired rate because of its specifity and affinity with the target.