Publication: Sulfamidas: aspectos farmacológicos y químico-farmacéuticos
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2016-02
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Abstract
Las sulfamidas constituyen un amplio grupo de fármacos que contienen en su estructura molecular un grupo sulfonamida y que pueden tener diversas indicaciones farmacológicas, siendo especialmente conocidas como antibióticos, siendo de hecho uno de los grupos más antiguos y estudiados de antibacterianos. Este trabajo de fin de grado consta de una revisión bibliográfica sobre los aspectos farmacológicos y quimico-farmaceúticos de estas moléculas. Además, como parte experimental del trabajo, se ha procedido a probar un protocolo de síntesis orgánica del sulfatiazol (uno de los fármacos más conocidos de este grupo) para fines didácticos utilizando el material de prácticas de laboratorio de Química Farmacéutica I disponible en el Departamento de Química Orgánica y Farmacéutica de la Facultad de Farmacia de la Universidad Complutense de Madrid, con el fin de añadir la reacción a dichas prácticas si se demostrase viable. Aunque la reacción parece haber tenido lugar de forma correcta y la apariencia física del producto es la esperada (un sólido marrón), los resultados de las pruebas de espectroscopia para identificar el producto no han sido totalmente concluyentes y se necesitan más estudios en el futuro para verificar la viabilidad de la reacción en dichas condiciones.
Sulfonamides are a large group of drugs containing in its molecular structure a sulfonamide group and can have various pharmacological indications, being especially known as antibiotics, being as a matter of fact one of the oldest and most studied of antibacterial groups. In this final year dissertation it has been reviewed the literature on pharmacological and chemical-pharmaceutical aspects of these molecules. In addition, as an experimental part of the study, we proceeded to test a protocol organic synthesis Sulfathiazole (one of the best known drugs of this group) for teaching purposes using the materials labs in Pharmaceutical Chemistry I available from the Department of Organic Chemistry and Pharmaceutical Faculty of Pharmacy of the Complutense University of Madrid, in order to add the reaction to the laboratory practices of this subject if it were shown feasible. Even though the reaction seems to have taken place correctly and the physical appeareance of the product is the one expected (a brown solid) the results of the spectrometry tests to identify the product have been inconclusive and further studies are needed in the future to verify the feasibility of the reaction under these conditions.
Sulfonamides are a large group of drugs containing in its molecular structure a sulfonamide group and can have various pharmacological indications, being especially known as antibiotics, being as a matter of fact one of the oldest and most studied of antibacterial groups. In this final year dissertation it has been reviewed the literature on pharmacological and chemical-pharmaceutical aspects of these molecules. In addition, as an experimental part of the study, we proceeded to test a protocol organic synthesis Sulfathiazole (one of the best known drugs of this group) for teaching purposes using the materials labs in Pharmaceutical Chemistry I available from the Department of Organic Chemistry and Pharmaceutical Faculty of Pharmacy of the Complutense University of Madrid, in order to add the reaction to the laboratory practices of this subject if it were shown feasible. Even though the reaction seems to have taken place correctly and the physical appeareance of the product is the one expected (a brown solid) the results of the spectrometry tests to identify the product have been inconclusive and further studies are needed in the future to verify the feasibility of the reaction under these conditions.