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Epidemiología de la fiebre Q en rumiantes domésticos en la zona central de la península ibérica

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García-Seco Romero, Teresa (2018) Epidemiología de la fiebre Q en rumiantes domésticos en la zona central de la península ibérica. [Thesis]

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Abstract

Coxiella burnetii es el agente etiológico de la fiebre Q, zoonosis que presenta unadistribución mundial y cuyo principal reservorio y fuente de infección para el hombre sonlos rumiantes domésticos. En estos, la principal consecuencia de la infección es el aborto,especialmente en el caso de pequeños rumiantes, estando más asociada a problemas defertilidad en el bovino. Tradicionalmente se ha considerado que la fiebre Q tenía unimpacto menor en la producción animal dada su frecuente presentación en forma deinfecciones inaparentes. Sin embargo, a lo largo de los años ha quedado demostrada lacapacidad de esta enfermedad para producir importantes brotes clínicos en rumiantes, yde hecho actualmente se considera una de las principales causas de aborto infeccioso enrumiantes domésticos. Los animales infectados excretan un elevado número de bacteriasen el momento del parto o del aborto, que contaminan el ambiente y pueden dar lugar anuevas infecciones de individuos susceptibles. La baja dosis infectiva de C. burnetii, sugran resistencia ambiental y su capacidad para desplazarse largas distancias con el vientola convierten en un patógeno altamente contagioso y cuya transmisión puede llegar a serdifícil de controlar. La transmisión al hombre se produce principalmente por vía aerógenaa través de la inhalación de aerosoles contaminados...

Resumen (otros idiomas)

Coxiella burnetii is the aetiological agent of Q fever, a worldwide distributed zoonosiswhose main reservoirs and source of infection for humans are domestic ruminants. Themain clinical sign associated with C. burnetii infection is late-term abortion in smallruminants, and fertility problems in cattle. However, the impact of Q fever in animalproduction has been traditionally considered limited since infection is more commonlyunapparent. Still, its ability to cause important clinical outbreaks has become evident inthe last years, so that nowadays it is considered one of the main causes of abortion indomestic ruminants. Infected animals may excrete high amounts of bacteria during theabortion/parturition, contaminating the environment and potentially leading to newinfections in susceptible individuals. The control of C. burnetii is difficult due to its lowinfective dose, its high environmental resistance and the potential for airbornetransmission events over long distances when conditions are favorable. In fact, airbornetransmission due to inhalation of contaminated aerosols is considered the main route ofinfection in humans.In humans, C. burnetii infection is also normally silent (in about 60% of the cases).However, in a proportion of causes it may cause acute and chronic infections that, inoccasions, may be highly incapacitating. Moreover, in certain cases the complication ofclinical signs may be fatal. These characteristics, together with the increasing number ofreported cases during the last decade (both sporadic as well as part of outbreaks affectingthousands of people, generally associated to domestic ruminants) have revealed thepotential clinical consequences this traditionally neglected disease can have in publichealth. Nevertheless, there are numerous knowledge gaps in several relevant clinical andepidemiological aspects of the disease...

Item Type:Thesis
Additional Information:

Tesis de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Sanidad Animal, leída el 22-06-2017

Directors:
DirectorsDirector email
Álvarez Sánchez, Julio
Pérez Sancho,, Marta
Goyache Goñi, Joaquín
Uncontrolled Keywords:Rumiantes
Palabras clave (otros idiomas):Rumiants
Subjects:Medical sciences > Veterinary > Veterinary pathology
ID Code:49584
Deposited On:17 Oct 2018 10:38
Last Modified:15 Nov 2018 10:28

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