Publication: Uso y abuso de estatinas
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2016-02
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Abstract
La hipercolesterolemia es un factor de riesgo importante en el desarrollo de enfermedades cardiovasculares. Las estatinas siguen siendo el tratamiento de elección para la dislipidemia y la disminución del riesgo cardiovascular. Constituyen un grupo terapéutico beneficioso, seguro y económico, razones por las que su consumo se ha cuadruplicado en los últimos diez años. Diversos estudios han demostrado que su mecanismo de acción da lugar a efectos adversos a nivel gastrointestinal, sistema nervioso periférico, neuromuscular y sobre el sistema endocrino entre otros. Estos efectos, pese a ser poco frecuentes, se debe tener en cuenta que su incidencia se incrementa con su consumo. Por ello, el objetivo del presente trabajo es aportar una clara visión de la situación clínica, explorar los mecanismos de acción posibles para los efectos adversos y determinar su prevalencia.
Hypercholesterolemia is a major risk factor in the development of cardiovascular diseases. Statins remain nowadays the treatment of choice for dyslipidemia and cardiovascular risk reduction. They constitute a beneficial, safe and affordable therapeutic group, that may be the reasons why consumption has quadrupled in the last ten years. Several studies have demonstrated that its mechanism of action result in gastrointestinal, neuromuscular, peripheral nervous system and endocrine system side effects, among others. Those effects, despite being rare, it should be noted that its incidence increases with consumption. Therefore, the main point of this study is to provide a vision of the clinical situation, explore the possible mechanisms of the side effects and to determine its prevalence.
Hypercholesterolemia is a major risk factor in the development of cardiovascular diseases. Statins remain nowadays the treatment of choice for dyslipidemia and cardiovascular risk reduction. They constitute a beneficial, safe and affordable therapeutic group, that may be the reasons why consumption has quadrupled in the last ten years. Several studies have demonstrated that its mechanism of action result in gastrointestinal, neuromuscular, peripheral nervous system and endocrine system side effects, among others. Those effects, despite being rare, it should be noted that its incidence increases with consumption. Therefore, the main point of this study is to provide a vision of the clinical situation, explore the possible mechanisms of the side effects and to determine its prevalence.