Publication: Efecto del estradiol y la progesterona sobre la migración y función de los neutrófilos en el tracto reproductor femenino inferior
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2018-11-21
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Universidad Complutense de Madrid
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Abstract
La mucosa del tracto reproductor femenino (TRF) debe conciliar las funciones reproductoras con la inmunidad para permitir la fecundación y mantener el embarazo. De esta forma, las hormonas sexuales femeninas no solo preparan el ambiente necesario para la reproducción, sino que también lo coordinan con el sistema inmune. Por ejemplo, a lo largo del ciclo ovárico existen variaciones en el número de neutrófilos en la vagina. Así, durante la fase folicular, los neutrófilos desaparecen dellumen vaginal, a la vez que aumenta la concentración de estradiol (E2). Tras la ovulación, los neutrófilos vuelven a infiltrarse en la vagina a lo largo de la fase lútea, coincidiendo con el pico de progesterona (P4)...
Female reproductive tract (FRT) must conciliate reproduction with immunity to allow fertilization and successfully maintain pregnancy. Female sex hormones not only produce the proper FRT mucosal environment, but also regulate immune components. Thus, neutrophil numbers fluctuate throughout the ovarian cycle in the vagina. During the follicular phase, while estradiol (E2) concentration increases, neutrophils disappear from the vaginal lumen. After ovulation, during the luteal phase, progesterone (P4) levels peak and neutrophils re-infiltrate the vagina. Current hypothesis holds that female sex hormones govern this phenomenon; however, the mechanisms that direct neutrophil migration to the vaginal lumen are still unknown. In this work, we demonstrate that E2, through the Esr1 receptor, blocks neutrophil transepithelial migration (TEpM) in the lower FRT by acting on the epithelium of the ectocervix and fornix...
Female reproductive tract (FRT) must conciliate reproduction with immunity to allow fertilization and successfully maintain pregnancy. Female sex hormones not only produce the proper FRT mucosal environment, but also regulate immune components. Thus, neutrophil numbers fluctuate throughout the ovarian cycle in the vagina. During the follicular phase, while estradiol (E2) concentration increases, neutrophils disappear from the vaginal lumen. After ovulation, during the luteal phase, progesterone (P4) levels peak and neutrophils re-infiltrate the vagina. Current hypothesis holds that female sex hormones govern this phenomenon; however, the mechanisms that direct neutrophil migration to the vaginal lumen are still unknown. In this work, we demonstrate that E2, through the Esr1 receptor, blocks neutrophil transepithelial migration (TEpM) in the lower FRT by acting on the epithelium of the ectocervix and fornix...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Microbiología I, leída el 11/12/2017