Publication: Modelo predictivo de mortalidad en pacientes con cáncer transicional de vejiga tratados con cistectomía radical
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2018-11-28
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Universidad Complutense de Madrid
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Abstract
El tumor de vejiga (TV) es el noveno tumor más frecuente y la catorceava causa de mortalidad con 165.084 muertes en 2012(GLOBOCAN). La cistectomía radical (CR) con linfadenectomía pélvica es tratamiento de elección en pacientes con tumor vesical músculoinfiltrante(TVMI). Los principales factores pronósticos de supervivencia tras CR que se repiten en la literatura son el estadio patológico local (pT) y la afectación ganglionar (pN).HIPÓTESIS Y OBJETIVOS: Los modelos predictivos se basan en variables pronosticas para cuantificar el riesgo, de forma individualizada, de desarrollar enfermedad, presentar recidiva o morir a causa de la enfermedad.El objetivo principal de esta tesis es elaborar un modelo predictivo de mortalidad a los 1, 3, y 5 años basándonos en variables clínicas pre-cirugía y patológicas post-cirugía en pacientes con tumor urotelial vesical (TUV) tratados con CR.MATERIAL Y MÉTODOS: Se realizó un análisis retrospectivo de 517 pacientes diagnosticados de TUV y tratados con CR entre 1986 y 2009 en el Servicio de Urología del Hospital General Universitario Gregorio Marañón(Madrid)...
Bladder cancer (BC) is the ninth most frequent tumour andthe 14th cause of mortality with 165,084 deaths in 2012 (GLOBOCAN). Radical cystectomy (RC) with pelvic lymphadenectomy is the treatment of choice in patients with muscle invasive bladder cancer (MIBC).The main prognostic factors for survival after RC that appear in the literature are local pathological stage (pT) and nodal involvement (pN).HYPOTHESIS AND OBJECTIVES: Predictive models quantify the individualized risk of developing disease, presenting relapse or dying from the disease based on prognostic variables.The main objective of this doctoral thesis is to elaborate a predictive model of mortality at 1, 3, and 5 years in patients with bladder transitional cell carcinoma treated with RC based on preoperative clinical and postoperative pathological variables. MATERIAL AND METHODS: A retrospective analysis of 517 patients diagnosed with BC and treated with RC between 1986 and 2009 was performed at the Urology Department of the Gregorio Marañón Hospital (Madrid)...
Bladder cancer (BC) is the ninth most frequent tumour andthe 14th cause of mortality with 165,084 deaths in 2012 (GLOBOCAN). Radical cystectomy (RC) with pelvic lymphadenectomy is the treatment of choice in patients with muscle invasive bladder cancer (MIBC).The main prognostic factors for survival after RC that appear in the literature are local pathological stage (pT) and nodal involvement (pN).HYPOTHESIS AND OBJECTIVES: Predictive models quantify the individualized risk of developing disease, presenting relapse or dying from the disease based on prognostic variables.The main objective of this doctoral thesis is to elaborate a predictive model of mortality at 1, 3, and 5 years in patients with bladder transitional cell carcinoma treated with RC based on preoperative clinical and postoperative pathological variables. MATERIAL AND METHODS: A retrospective analysis of 517 patients diagnosed with BC and treated with RC between 1986 and 2009 was performed at the Urology Department of the Gregorio Marañón Hospital (Madrid)...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 22/05/2017