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The role of zwitterionic materials in the fight against proteins and bacteria

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Colilla Nieto, Montserrat and Izquierdo Barba, Isabel and Vallet Regí, María (2018) The role of zwitterionic materials in the fight against proteins and bacteria. MEDICINES, 5(4) . p. 125. ISSN 2305-6320

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Official URL: https://www.mdpi.com/journal/medicines


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Abstract

Zwitterionization of biomaterials has been heightened to a potent tool to develop biocompatible materials able to inhibit bacterial and non-specific proteins adhesion. This constitutes a major progress in the biomedical field. This manuscript overviews the main functionalization strategies that have been reported up to date to design and develop these advanced biomaterials. On this regard, the recent research efforts dedicated to provide their surface of zwitterionic nature are summarized by classifying biomaterials in two main groups. First, we centre on biomaterials in clinical use, concretely bioceramics and metallic implants. Finally, we revise emerging nanostructured biomaterials, which are receiving growing attention due to their multifunctionality and versatility mainly in the local drug delivery and bone tissue regeneration scenarios.


Item Type:Article
Additional Information:

RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Biomaterials; zwitterionic surfaces; infection; bioceramics; bacterial inhibition.
Subjects:Sciences > Chemistry > Materials
ID Code:50361
Deposited On:11 Jan 2019 09:28
Last Modified:06 Mar 2019 09:03

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