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Biosynthesis and Biological Activity of Carbasugars



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Roscales, Silvia and Plumet, Joaquín (2016) Biosynthesis and Biological Activity of Carbasugars. International Journal of Carbohydrate Chemistry, 7 (31). pp. 1-42. ISSN 1687-9341

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Official URL: https://www.hindawi.com/journals/ijcc/2016/4760548/


The first synthesis of carbasugars, compounds in which the ring oxygen of a monosaccharide had been replaced by a methylene moiety, was described in 1966 by Prof. G.E. McCasland’s group. Seven years later, the first true natural carbasugar (5a-carba-R-D-galactopyranose) was isolated from a fermentation broth of Streptomyces sp. MA-4145. In the following decades, the chemistry and biology of carbasugars have been extensively studied. Most of these compounds show interesting biological properties, especially enzymatic inhibitory activities and, in consequence, an important number of analogues have also been prepared in the search for improved biological activities. The aim of this review is to give coverage on the progress made in two important aspects of these compounds: the elucidation of their biosynthesis and the consideration of their biological properties, including the extensively studied carbapyranoses as well as the much less studied carbafuranoses.

Item Type:Article
Subjects:Sciences > Chemistry > Chemistry, Organic
ID Code:50391
Deposited On:10 Dec 2018 10:00
Last Modified:10 Dec 2018 16:11

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