Publication: Sistemas de liberación modificada colónica para el tratamiento de enfermedades inflamatorias crónicas
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2016-02
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Abstract
En este trabajo se exploran las estrategias que ha desarrollado la Tecnología Farmacéutica para la liberación modificada colónica de principios activos (p.a.) en el tratamiento de tres enfermedades inflamatorias crónicas: la enfermedad de Crohn, la colitis ulcerosa y la artritis reumatoide. La modificación de la liberación es útil para el tratamiento de estas dolencias, que requieren tratamiento farmacológico de por vida. Además permiten evitar la inactivación precolónica del principio activo, incrementar la eficacia del tratamiento, reducir el número de administraciones y evitar efectos secundarios e intoxicaciones; lo que en última instancia mejora el cumplimiento del tratamiento, lo optimiza y aumenta la calidad de vida del paciente. Se estudiarán tres mecanismos de liberación de principio activo a nivel colónico, los sistemas de liberación modificada más relevantes y se verán algunos ejemplos de sistemas comercializados en España.
In this project, strategies to deliver drugs directly into the colon were explored to treat three chronic, inflammatory diseases: Crohn’s disease, ulcerative colitis and reumathoid arthritis. Delivering drugs into the colon is useful in chronic illnesses that require life-long treatments. Colonic drug-delivery systems avoid the loss of drug in pre-colonic areas, increase the treatment’s effectiveness and reduce the number of doses the patient needs to take, thus decreasing the incidence of side effects/intoxications. As a consequence, patient compliance, treatment optimization and quality of life are increased. Three mechanisms for the delivery of drugs specifically to the colon are studied, along with the most important colonic drug-delivery systems and examples of marketed colonic systems in Spain.
In this project, strategies to deliver drugs directly into the colon were explored to treat three chronic, inflammatory diseases: Crohn’s disease, ulcerative colitis and reumathoid arthritis. Delivering drugs into the colon is useful in chronic illnesses that require life-long treatments. Colonic drug-delivery systems avoid the loss of drug in pre-colonic areas, increase the treatment’s effectiveness and reduce the number of doses the patient needs to take, thus decreasing the incidence of side effects/intoxications. As a consequence, patient compliance, treatment optimization and quality of life are increased. Three mechanisms for the delivery of drugs specifically to the colon are studied, along with the most important colonic drug-delivery systems and examples of marketed colonic systems in Spain.