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Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with lowfouling and reduced cell uptake properties.

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Encinas, Noemí and Angulo, Mercedes and Astorga, Carlos and Colilla, Montserrat and Izquierdo Barba, Isabel and Vallet Regí, María (2018) Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with lowfouling and reduced cell uptake properties. Acta Biomateralia . ISSN 1742-7061 (In Press)

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Official URL: https://www.journals.elsevier.com/acta-biomaterialia


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Abstract

The design of drug delivery systems needs to consider biocompatibility and host body recognition for an adequate actuation. In this work, mesoporous silica nanoparticles (MSNs) surfaces were successfully modified with two silane molecules to provide mixed-charge brushes (-NH3 �/-PO3 €) and well evaluated in terms of surface properties, low-fouling capability and cell uptake in comparison to PEGylated MSNs. The modification process consists in the simultaneous direct-grafting of hydrolysable short chain amino (aminopropyl silanetriol, APST) and phosphonate-based (trihydroxy-silyl-propyl-methyl-phospho nate, THSPMP) silane molecules able to provide a pseudo-zwitterionic nature under physiological pH conditions. Results confirmed that both mixed-charge pseudo-zwitterionic MSNs (ZMSN) and PEG-MSN display a significant reduction of serum protein adhesion and macrophages uptake with respect to pristine MSNs. In the case of ZMSNs, this reduction is up to a 70–90% for protein adsorption and c.a. 60% for cellular uptake. This pseudo-zwitterionic modification has been focused on the aim of local treatment of bacterial infections through the synergistic effect between the inherent antimicrobial effect of mixed-charge system and the levofloxacin antibiotic release profile. These findings open promising future expectations for the effective treatment of bacterial infections through the use of mixed-charge pseudo-zwitterionic MSNs furtive to macrophages and with antimicrobial properties.


Item Type:Article
Additional Information:

RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica nanoparticles, Mixed-charge brushes, Pseudo-zwitterionic surface, Low-fouling properties, Macrophage uptake, Levofloxacin release, Antimicrobial properties
Subjects:Sciences > Chemistry > Materials
ID Code:50445
Deposited On:11 Jan 2019 13:12
Last Modified:06 Mar 2019 09:02

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