Publication: Caracterización anatomoclínica y molecular del cáncer colorrectal en adultos jóvenes y comparación con pacientes mayores de 65 años
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2019-01-30
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Universidad Complutense de Madrid
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Abstract
El cáncer colorrectal (CCR), constituye un problema de salud pública en los países industrializados, tanto por su elevada incidencia como por su mortalidad. A nivel mundial representa casi un 10% del total de cánceres y es el tercer tumor más incidente. En su etiología confluyen tanto causas genéticas como ambientales. Se estima que un 70-85% de los tumores colorrectales son de tipo esporádico y hasta un 30% del podrían tener un componente hereditario con familiares de primer o segundo grado afectados. Un 5-6% de la población desarrollará tumores asociados con síndromes hereditarios autosómicos dominantes.Existen tres vías de carcinogénesis implicadas en la producción y progresión del CCR, cada una con sus diferencias moleculares, clínicas e histopatológicas que pueden justificar, junto a otros mecanismos aún por descubrir, las diferentes características inmunofenotípicas del CCR en el adulto joven y en el paciente mayor...
Colorectal cancer (CRC) is a matter of the very greatest importance, and constitutes a major health issue in western countries, due to its high incidence and mortality. It accounts for almost 10% of all cancer cases and it is the third most commonly diagnosed worldwide.It can be originated from both genetic and environmental factors. Approximately 70-85% of CRC are sporadic, and it is estimated that up to 30% cases could be an inherited form of the disease with familial cases (first or second degree). Between 5-6% of the affected population will develop tumors associated with autosomal-dominant hereditary syndromes.There are three carcinogenesis path-ways implicated in the production and progression of CRC, each one has its molecular, clinical and histopathological differences that may justify, along with other mechanisms yet to be discovered, the different immunophenotypic characteristics of CRC in the young adult and in the elderly patient..
Colorectal cancer (CRC) is a matter of the very greatest importance, and constitutes a major health issue in western countries, due to its high incidence and mortality. It accounts for almost 10% of all cancer cases and it is the third most commonly diagnosed worldwide.It can be originated from both genetic and environmental factors. Approximately 70-85% of CRC are sporadic, and it is estimated that up to 30% cases could be an inherited form of the disease with familial cases (first or second degree). Between 5-6% of the affected population will develop tumors associated with autosomal-dominant hereditary syndromes.There are three carcinogenesis path-ways implicated in the production and progression of CRC, each one has its molecular, clinical and histopathological differences that may justify, along with other mechanisms yet to be discovered, the different immunophenotypic characteristics of CRC in the young adult and in the elderly patient..
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 19-04-2018