Publication: Actividad peri-operatoria del meloxicam durante la analgesia preventiva equilibrada en el perro
Loading...
Files
Official URL
Full text at PDC
Publication Date
2004
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
OBJETIVO.- Evaluar la eficacia analgésica del meloxicam en un programa de analgesia preventiva equilibrada en perros sometidos a cirugía ortopédica.
ANIMALES.- 24 perros, clasificados ASA I y programados a cirugía ortopédica.
PROCEDIMIENTO.- Después de la inducción, el mantenimiento anestésico se realizó con halotano vaporizado en oxígeno, y de manera aleatoria los animales fueron incluidos en cuatro grupos: GI (salino + salino), GII (0,2 mg/Kg meloxicam + salino), GIII (salino + 0,5 μg/Kg/min remifentanil), y GIV (0,2 mg/kg meloxicam + 0,5 μg/Kg/min remifentanil). Durante el procedimiento quirúrgico se evaluó la reducción de la concentración alveolar mínima del halotano (CAMHAL); además, se monitorizó de manera continua la frecuencia cardiaca, la presión arterial no invasiva, la saturación de oxígeno en hemoglobina, la frecuencia respiratoria, y la fracción espirada de CO2. Una vez finalizada la cirugía, se avaluó la analgesia post-operatoria.
RESULTADOS.- La CAMHAL se redujo hasta 0,6 ± 0,1 en el grupo I, 0,6 ± 0,1 en el grupo II, 0,3 ± 0,1 en el grupo III y 0,1 ± 0,1 en el grupo IV. La frecuencia cardiaca experimentó una disminución en los grupos de animales que recibieron la infusión continua intraoperatoria de remifentanilo y la presión arterial aumentó de manera estadísticamente significativa en todos los grupos. La evaluación de la analgesia postoperatoria demostró ser mejor en los grupos II y IV.
CONCLUSIONES.- La utilización de meloxicam en el periodo intraoperatorio no solo potencia la capacidad de los opiáceos en reducir la CAMHAL, sino también es de gran utilidad en proporcionar una adecuada analgesia postoperatoria cuando se incluye en un programa de analgesia preventiva equilibrada en cirugías ortopédicas en el perro.
OBJECTIVE.- To evaluate the analgesic efficacy of meloxicam when employed in program of balanced preemptive analgesia in dogs subjected to orthopedic surgery. ANIMALS.- 24 dogs, classified ASA I, requiring orthopedic surgery. PROCEDURE.- After induction, anaesthesia was maintained with halothane vaporized in oxygen and the animals were incorporated into four groups depending on which solutions was employed: GI (saline + saline), GII (0,2 mg/Kg bw meloxicam + saline), GIII (saline + 0,5 μg/Kg bw/min remifentanil), and GIV (0,2 mg/kg bw meloxicam + 0,5 μg/Kg bw/min remifentanil). During surgical procedure, reduction on the minimum alveolar concentration of halothane (MACHAL) was evaluated; and heart rate, non-invasive arterial blood pressure, hemoglobin oxygen saturation, rectal temperature, respiratory rate and end-tidal carbon dioxide were continuously monitoring. Once surgery was over, post-operative analgesia was assessed. RESULTS.- The MACHAL decreased to 0,6 ± 0,1 in group I, 0,6 ± 0,1 in group II, 0,3 ± 0,1 in group III, and 0,1 ± 0,1 in group IV. The heart rate decreased in the groups of animals that received continuous intra-operative infusion of remifentanil, and the arterial pressure rose significantly in all the groups. The evaluation of post-operative analgesia reveals better results in groups II and IV. CONCLUSIONS.- We confirmed not only the intra-operative efficacy of meloxicam in potentiating the capacity of opioids to reduce the MACHAL, but its post-operative utility in providing adequate analgesia when included in a program of pre-emptive analgesia for application in orthopedic surgery.
OBJECTIVE.- To evaluate the analgesic efficacy of meloxicam when employed in program of balanced preemptive analgesia in dogs subjected to orthopedic surgery. ANIMALS.- 24 dogs, classified ASA I, requiring orthopedic surgery. PROCEDURE.- After induction, anaesthesia was maintained with halothane vaporized in oxygen and the animals were incorporated into four groups depending on which solutions was employed: GI (saline + saline), GII (0,2 mg/Kg bw meloxicam + saline), GIII (saline + 0,5 μg/Kg bw/min remifentanil), and GIV (0,2 mg/kg bw meloxicam + 0,5 μg/Kg bw/min remifentanil). During surgical procedure, reduction on the minimum alveolar concentration of halothane (MACHAL) was evaluated; and heart rate, non-invasive arterial blood pressure, hemoglobin oxygen saturation, rectal temperature, respiratory rate and end-tidal carbon dioxide were continuously monitoring. Once surgery was over, post-operative analgesia was assessed. RESULTS.- The MACHAL decreased to 0,6 ± 0,1 in group I, 0,6 ± 0,1 in group II, 0,3 ± 0,1 in group III, and 0,1 ± 0,1 in group IV. The heart rate decreased in the groups of animals that received continuous intra-operative infusion of remifentanil, and the arterial pressure rose significantly in all the groups. The evaluation of post-operative analgesia reveals better results in groups II and IV. CONCLUSIONS.- We confirmed not only the intra-operative efficacy of meloxicam in potentiating the capacity of opioids to reduce the MACHAL, but its post-operative utility in providing adequate analgesia when included in a program of pre-emptive analgesia for application in orthopedic surgery.
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Patología Animal II, leída el 16-04-2004.