Publication: Estudio de las alteraciones endocrinas durante el uso de psicofármacos en la infancia y adolescencia a partir de una base de datos prospectiva en atención especializada del área VI
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2019-02-18
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Universidad Complutense de Madrid
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Abstract
La prescripción de antipsicóticos en niños y adolescentes ha aumentado en los últimos 25 años. El uso de los medicamentos antipsicóticos en la población pediátrica es considerado relativamente nuevo comparado con el uso en los adultos. Simultáneamente con este incremento de uso también se observa que el uso “off label” de antipsicóticos en la población pediátrica se ha incrementado en los últimos años, a pesar de la falta de datos de seguridad, especialmente en estudios a largo plazo. Los niños y adolescentes tienen una mayor susceptibilidad de aparición de reacciones adversas a los medicamentos y el riesgo de ineficacia aumenta en comparación con los adultos. Los niños no son solo diferentes a los adultos, sino además difieren mucho entre grupos de edad. El uso de los antipsicóticos de segunda generación se asocia a efectos cardiometabólicos y endocrinos. La hiperprolactinemia puede producir supresión de la hormona liberadora de gonadotrofina e hipogonadismo. Con el aumento del uso de medicamentos psicotrópicos en la población pediátrica, es crucial la realización de una monitorización de su seguridad para proporcionar un análisis informado de riesgo-beneficio en esta población...
The prescription of antipsychotics in children and adolescents has risen in the last 25 years. Simultaneously the "off label" use of antipsychotics in the pediatric population has also increased in recent years, despite the lack of safety data, especially on the long-term. Children and adolescents have a greater susceptibility to the appearance of adverse reactions to medications and the risk of ineffectiveness can be increased compared to adults. Children are not only different from adults, but they also differ greatly between age groups. Second generation of antipsychotics are associated with cardio metabolic and endocrine side-effects. Children and adolescents have a high probability to experience endocrine adverse events as hyperprolactinemia associated with antipsychotic use. Hyperprolactinemia could produce suppression of gonadotropin releasing hormone secretion and hypogonadism. With the increase in the use of psychotropic drugs in the pediatric population, it is crucial that the safety aspects are strictly monitored to provide an informed risk-benefit analysis of their use in this population...
The prescription of antipsychotics in children and adolescents has risen in the last 25 years. Simultaneously the "off label" use of antipsychotics in the pediatric population has also increased in recent years, despite the lack of safety data, especially on the long-term. Children and adolescents have a greater susceptibility to the appearance of adverse reactions to medications and the risk of ineffectiveness can be increased compared to adults. Children are not only different from adults, but they also differ greatly between age groups. Second generation of antipsychotics are associated with cardio metabolic and endocrine side-effects. Children and adolescents have a high probability to experience endocrine adverse events as hyperprolactinemia associated with antipsychotic use. Hyperprolactinemia could produce suppression of gonadotropin releasing hormone secretion and hypogonadism. With the increase in the use of psychotropic drugs in the pediatric population, it is crucial that the safety aspects are strictly monitored to provide an informed risk-benefit analysis of their use in this population...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 06/11/2018