Publication: Estudio in vivo de la eficacia del cemento óseo con rifampicina contenida en microcápsulas de alginato en el tratamiento de la infección protésica
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2019-02-19
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Universidad Complutense de Madrid
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Abstract
La infección periprotésica (PJI) es una complicación grave con incidencia creciente debido al aumento de la esperanza de vida de la población y a un aumento de la demanda funcional del paciente joven. La incidencia de PJI en la actualidad es del 2-2,4% pero se estima un incremento de la misma hasta suponer un 47,5% en 2030, posicionando la PJI como primera causa de revisión. Los principales agentes causales de la infección periprotésica son los estafilococos coagulasa negativos, suponiendo entre el 20-39% de los casos, seguidos por el Staphylococcus aureus, que supone entre el 13 y el 31% del total. Estos dos microorganismos al entrar en contacto con el material protésico son capaces de adherirse a él formando un biofilm, dando lugar a dos consecuencias inmediatas: aumenta la aparición de resistencias a antibióticos al actuar como barrera física para su penetración e inhibe la respuesta inmune del huésped. Por ello la presencia de un biofilm hace que las dosis efectivas de antibiótico se multipliquen de 200 a 1000 veces...
Prosthetic joint infection (PJI) is a serious complication with increasing incidence due to the increase in the life expectancy of the population and in the functional demand of young patients. Currently, the incidence of PJI is 2-2.4% but it is estimated to arise to 47.5% in 2030, positioning the PJI as the first cause of revision. Coagulase negative staphylococcus and Staphylococcus aureus are considered to be the main responsible agents of PJI, assuming the 20-39% and 13-31% of the cases respectively. Both are capable of adhere to the prosthetic material forming a biofilm, increasing the appearance of antibiotic resistance by acting as a physical barrier to its penetration and inhibiting the host’s immune response. Therefore, the presence of a biofilm raises the effective antibiotic dosis among 200 to 1000 times...
Prosthetic joint infection (PJI) is a serious complication with increasing incidence due to the increase in the life expectancy of the population and in the functional demand of young patients. Currently, the incidence of PJI is 2-2.4% but it is estimated to arise to 47.5% in 2030, positioning the PJI as the first cause of revision. Coagulase negative staphylococcus and Staphylococcus aureus are considered to be the main responsible agents of PJI, assuming the 20-39% and 13-31% of the cases respectively. Both are capable of adhere to the prosthetic material forming a biofilm, increasing the appearance of antibiotic resistance by acting as a physical barrier to its penetration and inhibiting the host’s immune response. Therefore, the presence of a biofilm raises the effective antibiotic dosis among 200 to 1000 times...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 05/11/2018