Universidad Complutense de Madrid
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The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies

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Herrero-Vanrell, Rocío and Bravo-Osuna, Irene and Andrés-Guerrero, Vanessa and Vicario-de-la-Torre, Marta and Molina-Martínez, Irene Teresa (2014) The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies. Progress in Retinal and Eye Research, 42 . pp. 27-43. ISSN 1350-9462

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Official URL: https://www.sciencedirect.com/journal/progress-in-retinal-and-eye-research



Abstract

Pathologies affecting the posterior segment are one of the major causes of blindness in developed countries and are becoming more prevalent due to the increase in society longevity. Sucessful therapy of diseases affecting the back of the eye requires effective concentrations of the active substance mantained during a long period of time in the intraocular target site. Treatment of vitreoretinal diseases often include repeated intravitreous injections that are associated with adverse effects. Local administration of biodegradable microspheres offers an excellent alternative to multiple administrations, as they are able to deliver the therapeutic molecule in a controlled fashion. Furthermore, injection of microparticles is performed without the need for surgical procedures. As most of the retinal diseases are multifactorial, microspheres result especially promising because they can be loaded with more than one active substance and complemented with the inclusion of additives with pharmacological properties. Personalized therapy can be easily achieved by changing the amount of administered microspheres. Contrary to non-biodegradable devices, biodegradable PLA and PLGA microspheres disappear from the site of administration after delivering the drug. Furthermore, microspheres prepared from these mentioned biomaterials are well tolerated after periocular and intravitreal injections in animals and humans. After injection, PLA and PLGA microspheres suffer aggregation behaving like an implant. Biodegradable microspheres are potential tools in regenerative medicine for retinal repair. According to the reported results, presumably a variety of microparticulate formulations for different ophthalmic therapeutic uses will be available in the clinical practice in the near future.


Item Type:Article
Uncontrolled Keywords:Microparticles, PLGA, Retina, Drug delivery, Controlled release
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Pharmacy
Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:54781
Deposited On:01 Apr 2019 15:12
Last Modified:02 Apr 2019 11:06

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