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Pharmaceuticalmicroscale and nanoscale approaches for efficient treatment of ocular diseases



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Bravo-Osuna, Irene and Andrés-Guerrero, Vanessa and Pastoriza Abal, Pilar and Molina-Martínez, I.T. and Herrero-Vanrell, R. (2016) Pharmaceuticalmicroscale and nanoscale approaches for efficient treatment of ocular diseases. Drug Delivery and Translational Research, 6 (6). pp. 686-707. ISSN 2190-393X (Print) 2190-3948 (Online)


Official URL: https://link.springer.com/journal/13346


Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the development of novel drug delivery systems to be used for ocular therapy. The location of the target site in the eye as well as the ophthalmic disease will determine the route of administration (topical, intraocular, periocular, and suprachoroidal administration) and the most adequate device.
In this review, we discuss the use of colloidal pharmaceutical systems (nanoparticles, liposomes, niosomes, dendrimers, and microemulsions), microparticles (microcapsules and microspheres), and hybrid systems (combination of different strategies) in the treatment of ophthalmic diseases. Emphasis has been placed in the therapeutic significance of each drug delivery system for clinical translation.

Item Type:Article
Uncontrolled Keywords:Microparticles, Microspheres, Nanotechnology, Nanoparticles, Ocular, Anterior segment, Posterior segment
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Pharmacy
Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:54792
Deposited On:01 Apr 2019 15:50
Last Modified:02 Apr 2019 10:42

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