Publication: Implicación de Cadherina-E en patologías tumorales humanas
Loading...
Official URL
Full text at PDC
Publication Date
2017-02
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Citations
Exportar
Abstract
La cadherina-E es un tipo de molécula de adhesión (CAM), encargada de la adhesión intercelular homófila dependiente de calcio entre cadherinas de células adyacentes y que desempeña un papel crítico en la diferenciación tisular y en el mantenimiento de la arquitectura epitelial. Esta codificada por el gen CDH1 y regulada por múltiples vías de señalización celular. La hipermetilación del promotor del gen CDH1, se postula como la modificación epigenética más común que explica la disminución de la expresión de cadherina-E. Su falta de función provoca una pérdida de la adhesión celular y se relaciona con las primeras etapas del tránsito epitelio-mesenquima (EMT), periodo que se caracteriza por un cambio fenotípico celular, con pérdida de polaridad y de carácter invasivo. La baja expresión de cadherina-E se ha observado en determinados tipos de cánceres como el de mama, gástrico o colorrectal y se ha correlacionado con un peor pronóstico para aquellos pacientes que no la expresan. Por ello se utiliza como biomarcador de pronóstico (sE-cad).
E-cadherin is a type of adhesion molecule (CAM) responsible for the homophile intercellular adhesion dependent on calcium between cadherins of adjacent cells. It also plays a critical role in tissue differentiation and on the maintenance of epithelial architecture. The E-cadherin is encoded by the CDH1 gene and regulated by multiples cellular signalling pathways. The hypermethylation of the CDH1 gene promoter is considered as the most common epigenetic modification that explain the decreasing of the E-cadherin expression. Its lack of function causes loss of cell adhesion what it’s related to the early stages of epithelialmesenchymal transit (EMT), a period characterized by a cellular phenotypic change with a loss of polarity and invasiveness. The low expression of E-cadherin has been observed in certain types of cancers such as the breast, gastric or colorectal cancer and has been associated with a worse prognosis for those patients who do not express it. It is therefore used as a prognostic biomarker (sE-cad).
E-cadherin is a type of adhesion molecule (CAM) responsible for the homophile intercellular adhesion dependent on calcium between cadherins of adjacent cells. It also plays a critical role in tissue differentiation and on the maintenance of epithelial architecture. The E-cadherin is encoded by the CDH1 gene and regulated by multiples cellular signalling pathways. The hypermethylation of the CDH1 gene promoter is considered as the most common epigenetic modification that explain the decreasing of the E-cadherin expression. Its lack of function causes loss of cell adhesion what it’s related to the early stages of epithelialmesenchymal transit (EMT), a period characterized by a cellular phenotypic change with a loss of polarity and invasiveness. The low expression of E-cadherin has been observed in certain types of cancers such as the breast, gastric or colorectal cancer and has been associated with a worse prognosis for those patients who do not express it. It is therefore used as a prognostic biomarker (sE-cad).