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Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep

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Gomez Cerezo, Natividad and Casarrubios, Laura and Saiz-Pardo, M. and Ortega, L. and De Pablo, D. and Díaz-Güemes, I. and Fernández-Tomé, E. and Enciso, S and Sanchez-Margallo, F. M. and Portolés Pérez, María Teresa and Arcos Navarrete, Daniel and Vallet Regí, María (2019) Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep. Acta Biomaterialia . ISSN 1742-7061 (In Press)

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Official URL: https://www.journals.elsevier.com/acta-biomaterialia


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Abstract

Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and ɛpolycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. In vivo studies were carried out by implantation into cavitary defects drilled in osteoporotic sheep. The scaffolds evidenced excellent bone regeneration properties, promoting new bone formation at both the peripheral and the inner parts of the scaffolds, thick trabeculae, high vascularization and high presence of osteoblasts and osteoclasts. In order to evaluate the effects of the local release of an antiosteoporotic drug, 1% (%wt) of zoledronic acid was incorporated to the scaffolds. The scaffolds loaded with zoledronic acid induced apoptosis in Saos 2 cells, impeded osteoclast differentiation in a time dependent manner and inhibited bone healing, promoting an intense inflammatory response in osteoporotic sheep.


Item Type:Article
Additional Information:

RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous bioactive glass; Scaffolds; Osteoporosis; Zoledronic acid; Bone regeneration.
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:54945
Deposited On:09 Apr 2019 09:52
Last Modified:09 Apr 2019 12:17

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