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Efficacy of Ologen matrix implant in Ahmed Glaucoma Valve Implantation

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Sastre Ibáñez, Marina and Cabarga del Nozal, Carmen and Canut Jordana, Mª Isabel and Pérez Bartolomé, Francisco and Urcelay Segura, José Luis and Cordero Ros, Rosa Mª and García Feijoo, Julián and Martínez de la Casa, Jose Maria (2019) Efficacy of Ologen matrix implant in Ahmed Glaucoma Valve Implantation. Scientific Reports (9). nº 3178. ISSN 2045-2322

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Official URL: https://doi.org/10.1038/s41598-019-38656-x




Abstract

To determine the efficacy and safety of the Ologen collagen matrix adjunctive to Ahmed valve surgery. A randomized prospective multicentre clinical trial involving 58 patients that were followed for one year. Conventional surgery with Ahmed valve was performed in 31 eyes (Control group/CG) and in 27 Ologen (Ologen group/OG) was placed over the valve’s plate. Baseline data: age, corneal thickness, intraocular pressure(IOP) and antiglaucoma medications.Postoperative data (days 1, 7 and months 1, 3, 6 and 12): IOP, antiglaucoma medications, visual acuity and complications were recorded. Frequency of hypertensive phase, complete and qualified success and survival rate were studied. No differences were found between CG and OG in the baseline data. The only difference between groups was a significantly lower IOP at day 1. No other differences were found in the follow-up between groups. Hypertensive phase (56%CG and 55%OG, p = 0,947), complete success 28,6%CG and 30,4%OG (p = 0,88) and qualified success 96,4% and 95,9%(p = 0,794). Survival rates at 1 year were 76,7%(CG) and 69,2%(OG)(p = 0,531). 38,7% of patients in the CG suffered some complication during follow-up and 61,5% in OG(p = 0,086). Ologen does not increase safety or efficacy in Ahmed valve surgery at one-year follow-up. This is the first study that shows no benefit of Ologen adjunctive to this surgery.


Item Type:Article
Uncontrolled Keywords:Glaucoma; Surgery; Ologen matrix; Ahmed valve
Subjects:Medical sciences > Medicine > Surgery
Medical sciences > Medicine > Ophtalmology
ID Code:54997
Deposited On:12 Apr 2019 10:49
Last Modified:12 Apr 2019 11:32

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