Publication: Desarrollo de un modelo de periodontitis en ratas obesas. Papel de la melatonina
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2019-04-23
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Universidad Complutense de Madrid
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Abstract
La obesidad es una de las enfermedades más relevantes del mundo. En los últimos años ha sido considerada como una enfermedad multifactorial,caracterizada por una inflamación crónica que se relaciona con otras enfermedades como el desarrollo de diabetes, enfermedades cardiovasculares o la periodontitis. La periodontitis se define como una enfermedad inflamatoria crónica multifactorial asociada a un proceso de disbiosis de la placa dental y caracterizada por la destrucción progresiva de los tejidos de soporte del diente. A pesar de que se ha puesto de manifiesto la existencia de una relación entre la obesidad y la periodontitis, no están bien definidos cuáles son los mecanismos moleculares que las relacionan. Existe evidencia de un descenso de los niveles circulantes de melatonina, tanto en estudios en el hombre como en animales, cuando se desarrolla obesidad. Además, existen estudios en pacientes con periodontitis donde se observa este mismo fenómeno, pero no existen estudios en los que se analicen las concentraciones de melatonina cuando estas dos enfermedades coexisten en el mismo individuo. Esto abre una vía de investigación hacia el posible papel de la melatonina en la relación entre la obesidad y la periodontitis...
Obesity is a major health issue. In recent years, obesity has been considered a multifunctional disease, characterized by the existence of chronic inflammation and dispersed comorbidities which go from diabetes, through cardiovascular problems to periodontitis. Periodontitis is a chronic multifactorial inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Although the relationship between these two diseases, obesity and periodontitis is well established, the under-lined connecting mechanisms among them are not clear. Previous reports from the literature supports that a decrease in melatonin’s circulating levels in obesity not only in humans but also in rodents. In addition, while a decrease of the hormone melatonin has been found in patients suffering from periodontitis there are not researches exploring what happen when these two diseases coexist in the same individual. Furthermore, lack of research expands to the possible role of melatonin within obesity and/or periodontitis...
Obesity is a major health issue. In recent years, obesity has been considered a multifunctional disease, characterized by the existence of chronic inflammation and dispersed comorbidities which go from diabetes, through cardiovascular problems to periodontitis. Periodontitis is a chronic multifactorial inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Although the relationship between these two diseases, obesity and periodontitis is well established, the under-lined connecting mechanisms among them are not clear. Previous reports from the literature supports that a decrease in melatonin’s circulating levels in obesity not only in humans but also in rodents. In addition, while a decrease of the hormone melatonin has been found in patients suffering from periodontitis there are not researches exploring what happen when these two diseases coexist in the same individual. Furthermore, lack of research expands to the possible role of melatonin within obesity and/or periodontitis...
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Tesis inédita de la Universidad Complutense de Madrid de la Facultad de Odontología. Departamento de Especialidades Clínicas Odontológicas, leída el 19-12-2018