Publication: Distribución y efectos del piretroide ciflutrin sobre el sistema nervioso central
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2019-04-26
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Universidad Complutense de Madrid
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Abstract
Los piretroides son insecticidas sintéticos que presentan una amplia variedad de usos. Ciflutrin es un insecticida piretroide de Tipo II de amplio espectro utilizado en agricultura, en medicina veterinaria, en medicina humana y a nivel residencial en forma de aerosol. El sistema nervioso es el principal sitio de acción de los piretroides, debido a su efecto sobre los canales de sodio voltaje-dependientes, así como sobre los canales de calcio y su interacción con el receptor ionóforo de GABA. Aunque inicialmente se atribuía a los piretroides una baja toxicidad en mamíferos, diversos estudios han demostrado su efecto neurotóxico en roedores y otros animales, produciendo en ratas el síndrome CS, que se caracteriza por salivación, ataxia, hiperexcitación, convulsiones y parálisis. Existe información limitada sobre la distribución de ciflutrin y sus efectos sobre los niveles de monoaminas en el sistema nervioso central (SNC). El presente trabajo de investigación incluye dos objetivos: (i) El estudio toxicocinético de ciflutrinen ratas Wistar macho tras administración de dosis única intravenosa (IV) (3 mg/kgp.c.) y oral (20 mg/kg p.c.), y (ii) evaluar el efecto de ciflutrin, tras administración oral (1, 5, 10 y 20 mg/kg p.c., 6 días), sobre los niveles de monoaminas en regiones cerebrales de ratas Wistar macho...
Pyrethroids are synthetic insecticides used in a wide variety of applications. Cyfluthrin is a broad spectrum Type II pyrethroid insecticide, largely used in agriculture, in human and veterinary medicine and added even in household spray formulations. The nervous system is the main target, mainly due to its effect on voltagesodium channels, as well as on calcium channels and to its interaction with the GABA receptor-ionophore complex. Although initially considered to have a low toxicity in mammals, studies have been conducted to evaluate pyrethroids neurotoxicity in rodents and other animals, causing in rats the CS-syndrome, characterized by salivation, ataxia, hyperexcitation, convulsions, and paralysis. There is limited information about the toxicokinetics of cyfluthrin and its effects on the monoamines levels in the central nervous system (CNS). The present investigation includes two objectives: i) to study in male Wistar rats the toxicokinetics of cyfluthrin after single intravenous (IV) (3 mg/kgbw) and oral (20 mg/kg bw) doses, and ii) to examine in male Wistar rats the effects of cyfluthrin after oral exposure (1, 5, 10 and 20 mg/kg bw, 6 days) on brain region monoamine levels...
Pyrethroids are synthetic insecticides used in a wide variety of applications. Cyfluthrin is a broad spectrum Type II pyrethroid insecticide, largely used in agriculture, in human and veterinary medicine and added even in household spray formulations. The nervous system is the main target, mainly due to its effect on voltagesodium channels, as well as on calcium channels and to its interaction with the GABA receptor-ionophore complex. Although initially considered to have a low toxicity in mammals, studies have been conducted to evaluate pyrethroids neurotoxicity in rodents and other animals, causing in rats the CS-syndrome, characterized by salivation, ataxia, hyperexcitation, convulsions, and paralysis. There is limited information about the toxicokinetics of cyfluthrin and its effects on the monoamines levels in the central nervous system (CNS). The present investigation includes two objectives: i) to study in male Wistar rats the toxicokinetics of cyfluthrin after single intravenous (IV) (3 mg/kgbw) and oral (20 mg/kg bw) doses, and ii) to examine in male Wistar rats the effects of cyfluthrin after oral exposure (1, 5, 10 and 20 mg/kg bw, 6 days) on brain region monoamine levels...
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Tesis de la Universidad Complutense de Madrid, Facultad de Veterinaria, leída el 13-09-2018