Publication: Caracterización y producción de β-NGF y su papel en la fisiología reproductiva del conejo
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2019-05-06
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Universidad Complutense de Madrid
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Abstract
El factor de crecimiento nervioso (β-NGF) es una neurotrofina que se descubrió en el sistema nervioso y, posteriormente, en numerosas partes del organismo, entre ellos el sistema reproductor de muchas especies animales. Presenta importantes funciones durante el desarrollo de los órganos reproductores, como la espermatogénesis, la foliculogénesis, la maduración de los gametos y la ovulación. De hecho, se ha demostrado que es el denominado factor inductor de la ovulación (OIF) en especies de ovulación inducida, como los camélidos. En conejos, la presencia del sistema β-NGF (neurotrofina y sus dos receptores) se ha confirmado en algunos órganos masculinos (testículos, próstata y glándulas seminales) y femeninos (ovarios, oviducto, útero y cérvix) de animales adultos, pero no se ha caracterizado su papel durante el desarrollo sexual ni se conoce su relación con otras hormonas importantes en la reproducción, como la testosterona. Aunque el conejo es una especie de ovulación inducida, hasta el momento no se ha demostrado si el β-NGF provoca la ovulación como en camélidos puesto que los estudios realizados no han obtenido una respuesta ovulatoria adecuada con plasma seminal (PS) homólogo ni heterólogo, ni con β-NGF de origen murino...
The beta nerve growth factor (β-NGF) is a neurotrophin that was first discovered in the nervous system and then in other systems, such as the reproductive tract in many different species. In this system, it participates in the spermatogenesis and foliculogenesis, in gamete maturation and in the process of ovulation. In fact, it has been demonstrated that β-NGF is the ovulating-induction factor (OIF) in some reflex ovulator species, such as camelids. In rabbits, this factor and its two receptors (β-NGF system) are present in some tissues of male (testes, prostate and seminal glands) and female (ovary, oviduct, uterus and cervix) reproductive tract in adult animals. However, its role during sexual development and its relationship to some important hormones in reproduction, such as testosterone, are still unknown in this species. Furthermore, the ovulation in rabbits is induced by copulation but there is no clear evidence that β-NGF provokes the ovulation like in camelids, since neither murine β-NGF nor homologous or heterologous seminal plasma (SP) are able to trigger an appropriate ovarian response...
The beta nerve growth factor (β-NGF) is a neurotrophin that was first discovered in the nervous system and then in other systems, such as the reproductive tract in many different species. In this system, it participates in the spermatogenesis and foliculogenesis, in gamete maturation and in the process of ovulation. In fact, it has been demonstrated that β-NGF is the ovulating-induction factor (OIF) in some reflex ovulator species, such as camelids. In rabbits, this factor and its two receptors (β-NGF system) are present in some tissues of male (testes, prostate and seminal glands) and female (ovary, oviduct, uterus and cervix) reproductive tract in adult animals. However, its role during sexual development and its relationship to some important hormones in reproduction, such as testosterone, are still unknown in this species. Furthermore, the ovulation in rabbits is induced by copulation but there is no clear evidence that β-NGF provokes the ovulation like in camelids, since neither murine β-NGF nor homologous or heterologous seminal plasma (SP) are able to trigger an appropriate ovarian response...
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Tesis de la Universidad Complutense de Madrid, Facultad de Veterinaria, Sección Departamental de Fisiología (Veterinaria), leída el 05-12-2018