Publication: Análisis de la heterogeneidad del reciclamiento vesicular y mecanismos implicados en su regulación. Estudio en un modelo de X-Frágil
Loading...
Official URL
Full text at PDC
Publication Date
2019-05-07
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
El flujo de información en el cerebro se basa en el establecimiento de contactos neuronales o sinapsis, que traducen las señales eléctricas en señales químicas y viceversa. Este proceso ocurre al liberarse mensajeros químicos o neurotransmisores almacenados en vesículas sinápticas (VSs) desde una neurona presináptica y ser reconocidos por receptores específicos localizados en las espinas dendríticas de la neurona postsináptica (Sudhof 2012b). Para que este proceso tenga lugar, es necesario que las VSs sean transferidas desde el interior del terminal sináptico hacia la zona activa y, una vez allí, éstas sean ancladas ("docked") y sometidas a un proceso de maduración funcional ("priming"), que las hace competentes para la exocitosis cuando llega un potencial de acción (Jahn & Fasshauer 2012, Sudhof2012a). Una vez se han fusionado las VSs con la membrana plasmática y han liberado el neurotransmisor a la hendidura sináptica, las VSs son recicladas mediante diferentes mecanismos de endocitosis que permiten que, tras ser rellenadas con neurotransmisor, estén funcionalmente disponibles para volver a ser liberadas con una nueva estimulación. Todo este proceso, en su conjunto, es lo que se conoce como ciclo vesicular...
In the brain the flow of information is based on the establishment of neural contacts or synapses, which converts electrical signals into chemical signals and vice versa. This process occurs when chemical messengers or neurotransmitters stored in synaptic vesicles are released from a presynaptic neuron and are recognized by specific receptors on the dendritic spines of the postsynaptic neuron (Sudhof 2012b). For this process to take place, it is necessary the trafficking of the synaptic vesicles (SVs) from inside the synaptic terminal to the active zone, and once there they are anchored ("docked") and subjected to a functional maturation process ("priming") that makes them competent for exocytosis before the arrival of an action potential (Jahn &Fasshauer 2012, Sudhof 2012a). Once SVs have been fused with the plasma membrane and have released the neurotransmitter to the synaptic cleft, SVs are recycled by different mechanisms of endocytosis that allow them to be functionally available, after being refilled with neurotransmitter, to be released upon a new stimulation. All together, this process is known as vesicular cycle...
In the brain the flow of information is based on the establishment of neural contacts or synapses, which converts electrical signals into chemical signals and vice versa. This process occurs when chemical messengers or neurotransmitters stored in synaptic vesicles are released from a presynaptic neuron and are recognized by specific receptors on the dendritic spines of the postsynaptic neuron (Sudhof 2012b). For this process to take place, it is necessary the trafficking of the synaptic vesicles (SVs) from inside the synaptic terminal to the active zone, and once there they are anchored ("docked") and subjected to a functional maturation process ("priming") that makes them competent for exocytosis before the arrival of an action potential (Jahn &Fasshauer 2012, Sudhof 2012a). Once SVs have been fused with the plasma membrane and have released the neurotransmitter to the synaptic cleft, SVs are recycled by different mechanisms of endocytosis that allow them to be functionally available, after being refilled with neurotransmitter, to be released upon a new stimulation. All together, this process is known as vesicular cycle...
Description
Tesis de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Bioquímica y Biología Molecular, leída el 11-02-2019