Publication: Deterioro cognitivo subjetivo como marcador preclínico fiable en enfermedad de Alzheimer
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2019-05-14
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Universidad Complutense de Madrid
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Abstract
La demencia es un síndrome clínico caracterizado por un deterioro cognitivo progresivo, lo suficientemente severo como para impedir un funcionamiento autónomo a nivel personal y social del individuo. La enfermedad de Alzheimer (EA) representa la primera causa de demencia en nuestro país. Según datos del Centro Nacional de Epidemiología, el 7,3% de la población mayor de 65 años podría padecer esta enfermedad en la actualidad. En total, la EA constituye alrededor del 75% de la etiología de las demencias, bien de forma aislada bien en combinación con la patología cerebrovascular. Como consecuencia del incremento de la esperanza de vida y del progresivo envejecimiento de la población en los países occidentales, la demencia representa un enorme reto para los sistemas de salud públicos. En nuestro país, se estima que en el año 2050 un tercio de la población tendrá más de 65 años, por lo que aproximadamente un millón de españoles podría padecer demencia...
Alzheimer's disease (AD) is the leading cause of dementia in our environment. According to the National Epidemiology Center, 7.3% of the population over 65 years could suffer from this disease nowadays. In total, AD constitutes about 75% of the etiology of dementias, either alone or in combination with cerebrovascular disease. Because of increased life expectancy and the progressive aging of the population in Western countries, dementia represents a huge challenge for public health systems. In our country, it is estimated that by 2050 a third of the population will be over 65 years, so that approximately one million Spaniards could have dementia by then.AD is a silent disease that begins with brain degeneration many years before the first clinical diagnostic is noticeable. There is a long asymptomatic phase. The transition from a cognitively healthy stage to an AD-type dementia is a continuum in which some intermediate stages, preclinical and prodromal can be recognized. These stages are characterized by the presence of an incipient cognitive impairment that increases the probability of conversion to dementia in the future. An effective therapeutic intervention in these phases prior to AD could eventually slow the progression of deterioration and thus reduce the prevalence of the disease. For this reason, one of the challenges currently faced by research is the development of useful tools that allow early diagnosis of AD...
Alzheimer's disease (AD) is the leading cause of dementia in our environment. According to the National Epidemiology Center, 7.3% of the population over 65 years could suffer from this disease nowadays. In total, AD constitutes about 75% of the etiology of dementias, either alone or in combination with cerebrovascular disease. Because of increased life expectancy and the progressive aging of the population in Western countries, dementia represents a huge challenge for public health systems. In our country, it is estimated that by 2050 a third of the population will be over 65 years, so that approximately one million Spaniards could have dementia by then.AD is a silent disease that begins with brain degeneration many years before the first clinical diagnostic is noticeable. There is a long asymptomatic phase. The transition from a cognitively healthy stage to an AD-type dementia is a continuum in which some intermediate stages, preclinical and prodromal can be recognized. These stages are characterized by the presence of an incipient cognitive impairment that increases the probability of conversion to dementia in the future. An effective therapeutic intervention in these phases prior to AD could eventually slow the progression of deterioration and thus reduce the prevalence of the disease. For this reason, one of the challenges currently faced by research is the development of useful tools that allow early diagnosis of AD...
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Tesis de la Universidad Complutense de Madrid, Facultad de Psicología, leída el 13-12-2018